A role for alcohol dehydrogenase in the Drosophila immune response?

T. A. Schlenke, K. A. McKean

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In a recent study Drosophila larvae were injected with bacterial lipopolysaccharide (LPS) suspended in 1% ethanol and differentially induced protein fractions were identified. The levels of several proteins, including alcohol dehydrogenase (ADH), increased in LPS-treated flies and were labelled as immune response proteins. However, because control larvae were not injected with ethanol alone the identified proteins could represent a response to ethanol. Here, we injected Drosophila larvae with combinations of ethanol and LPS. While ADH activity increased in larvae receiving 1% ethanol, it was not increased after LPS injection. These results suggest that ADH plays no role in the Drosophila immune response, and that other proteins identified in the previous study may instead mediate ethanol tolerance in flies and other organisms.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalInsect Molecular Biology
Volume14
Issue number2
DOIs
StatePublished - Apr 2005
Externally publishedYes

Keywords

  • Drosophila
  • Ethanol tolerance
  • Immune response

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Insect Science

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