A review of responsive MRI contrast agents: 2005-2014

Dina V. Hingorani; Adam S. Bernstein; Mark D. Pagel

doi:10.1002/cmmi.1629

A review of responsive MRI contrast agents: 2005-2014

Dina V. Hingorani, Adam S. Bernstein, Mark D. Pagel

Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

166 Scopus citations

Abstract

This review focuses on MRI contrast agents that are responsive to a change in a physiological biomarker. The response mechanisms are dependent on six physicochemical characteristics, including the accessibility of water to the agent, tumbling time, proton exchange rate, electron spin state, MR frequency or superparamagnetism of the agent. These characteristics can be affected by changes in concentrations or activities of enzymes, proteins, nucleic acids, metabolites, or metal ions, or changes in redox state, pH, temperature, or light. A total of 117 examples are presented, including ones that employ nuclei other than ¹H, which attests to the creativity of multidisciplinary research efforts to develop responsive MRI contrast agents.

Original language	English (US)
Pages (from-to)	245-265
Number of pages	21
Journal	Contrast Media and Molecular Imaging
Volume	10
Issue number	4
DOIs	https://doi.org/10.1002/cmmi.1629
State	Published - Jul 1 2015

Keywords

CEST agents
Hyperpolarized agents
MRI contrast agents
MRS agents
Responsive agents
T
T agents
agents

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/cmmi.1629

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abstract = "This review focuses on MRI contrast agents that are responsive to a change in a physiological biomarker. The response mechanisms are dependent on six physicochemical characteristics, including the accessibility of water to the agent, tumbling time, proton exchange rate, electron spin state, MR frequency or superparamagnetism of the agent. These characteristics can be affected by changes in concentrations or activities of enzymes, proteins, nucleic acids, metabolites, or metal ions, or changes in redox state, pH, temperature, or light. A total of 117 examples are presented, including ones that employ nuclei other than 1H, which attests to the creativity of multidisciplinary research efforts to develop responsive MRI contrast agents.",

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A review of responsive MRI contrast agents: 2005-2014

Abstract

Keywords

ASJC Scopus subject areas

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