A Review of Autologous Stem Cell Transplantation in Lymphoma

Umar Zahid; Faisal Akbar; Akshay Amaraneni; Muhammad Husnain; Onyee Chan; Irbaz Bin Riaz; Ali McBride; Ahmad Iftikhar; Faiz Anwer

doi:10.1007/s11899-017-0382-1

A Review of Autologous Stem Cell Transplantation in Lymphoma

Umar Zahid, Faisal Akbar, Akshay Amaraneni, Muhammad Husnain, Onyee Chan, Irbaz Bin Riaz, Ali McBride, Ahmad Iftikhar, Faiz Anwer

Medicine

Research output: Contribution to journal › Review article › peer-review

88 Scopus citations

Abstract

Purpose of Review: Chemotherapy remains the first-line therapy for aggressive lymphomas. However, 20–30% of patients with non-Hodgkin lymphoma (NHL) and 15% with Hodgkin lymphoma (HL) recur after initial therapy. We want to explore the role of high-dose chemotherapy (HDT) and autologous stem cell transplant (ASCT) for these patients. Recent Findings: There is some utility of upfront consolidation for-high risk/high-grade B-cell lymphoma, mantle cell lymphoma, and T-cell lymphoma, but there is no role of similar intervention for HL. New conditioning regimens are being investigated which have demonstrated an improved safety profile without compromising the myeloablative efficiency for relapsed or refractory HL. Summary: Salvage chemotherapy followed by HDT and rescue autologous stem cell transplant remains the standard of care for relapsed/refractory lymphoma. The role of novel agents to improve disease-related parameters remains to be elucidated in frontline induction, disease salvage, and high-dose consolidation or in the maintenance setting.

Original language	English (US)
Pages (from-to)	217-226
Number of pages	10
Journal	Current Hematologic Malignancy Reports
Volume	12
Issue number	3
DOIs	https://doi.org/10.1007/s11899-017-0382-1
State	Published - Jun 1 2017

Keywords

Autologous stem cell transplantation
High-dose chemotherapy
Lymphoma
Novel agents
Relapsed/refractory
Salvage chemotherapy

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1007/s11899-017-0382-1

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abstract = "Purpose of Review: Chemotherapy remains the first-line therapy for aggressive lymphomas. However, 20–30% of patients with non-Hodgkin lymphoma (NHL) and 15% with Hodgkin lymphoma (HL) recur after initial therapy. We want to explore the role of high-dose chemotherapy (HDT) and autologous stem cell transplant (ASCT) for these patients. Recent Findings: There is some utility of upfront consolidation for-high risk/high-grade B-cell lymphoma, mantle cell lymphoma, and T-cell lymphoma, but there is no role of similar intervention for HL. New conditioning regimens are being investigated which have demonstrated an improved safety profile without compromising the myeloablative efficiency for relapsed or refractory HL. Summary: Salvage chemotherapy followed by HDT and rescue autologous stem cell transplant remains the standard of care for relapsed/refractory lymphoma. The role of novel agents to improve disease-related parameters remains to be elucidated in frontline induction, disease salvage, and high-dose consolidation or in the maintenance setting.",

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AU - Akbar, Faisal

AU - Amaraneni, Akshay

AU - Husnain, Muhammad

AU - Chan, Onyee

AU - Riaz, Irbaz Bin

AU - McBride, Ali

AU - Iftikhar, Ahmad

AU - Anwer, Faiz

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Y1 - 2017/6/1

N2 - Purpose of Review: Chemotherapy remains the first-line therapy for aggressive lymphomas. However, 20–30% of patients with non-Hodgkin lymphoma (NHL) and 15% with Hodgkin lymphoma (HL) recur after initial therapy. We want to explore the role of high-dose chemotherapy (HDT) and autologous stem cell transplant (ASCT) for these patients. Recent Findings: There is some utility of upfront consolidation for-high risk/high-grade B-cell lymphoma, mantle cell lymphoma, and T-cell lymphoma, but there is no role of similar intervention for HL. New conditioning regimens are being investigated which have demonstrated an improved safety profile without compromising the myeloablative efficiency for relapsed or refractory HL. Summary: Salvage chemotherapy followed by HDT and rescue autologous stem cell transplant remains the standard of care for relapsed/refractory lymphoma. The role of novel agents to improve disease-related parameters remains to be elucidated in frontline induction, disease salvage, and high-dose consolidation or in the maintenance setting.

AB - Purpose of Review: Chemotherapy remains the first-line therapy for aggressive lymphomas. However, 20–30% of patients with non-Hodgkin lymphoma (NHL) and 15% with Hodgkin lymphoma (HL) recur after initial therapy. We want to explore the role of high-dose chemotherapy (HDT) and autologous stem cell transplant (ASCT) for these patients. Recent Findings: There is some utility of upfront consolidation for-high risk/high-grade B-cell lymphoma, mantle cell lymphoma, and T-cell lymphoma, but there is no role of similar intervention for HL. New conditioning regimens are being investigated which have demonstrated an improved safety profile without compromising the myeloablative efficiency for relapsed or refractory HL. Summary: Salvage chemotherapy followed by HDT and rescue autologous stem cell transplant remains the standard of care for relapsed/refractory lymphoma. The role of novel agents to improve disease-related parameters remains to be elucidated in frontline induction, disease salvage, and high-dose consolidation or in the maintenance setting.

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KW - Novel agents

KW - Relapsed/refractory

KW - Salvage chemotherapy

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A Review of Autologous Stem Cell Transplantation in Lymphoma

Abstract

Keywords

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