Abstract
The maintenance of the sterility of craniotomies for serial acute neurophysiological recordings is exacting and time consuming yet is vital to the health of valuable experimental animals. We have developed a method to seal the craniotomy with surgical grade silicone elastomer (Silastic®) in a hermetically sealed chamber. Under these conditions the tissues in the craniotomy and the inside surface of the chamber remain unpopulated by bacteria. The silicone elastomer sealant retarded the growth of granulation tissue on the dura and reduced the procedures required to maintain ideal conditions for neurophysiological recordings.
Original language | English (US) |
---|---|
Pages (from-to) | 23-26 |
Number of pages | 4 |
Journal | Journal of Neuroscience Methods |
Volume | 169 |
Issue number | 1 |
DOIs | |
State | Published - Mar 30 2008 |
Keywords
- Craniotomy
- Dura mater
- Granulation tissue
- Monkey
- Neurophysiology
- Silastic
- Silicone elastomer
ASJC Scopus subject areas
- General Neuroscience