A removable silicone elastomer seal reduces granulation tissue growth and maintains the sterility of recording chambers for primate neurophysiology

Kevin M. Spitler; Katalin M. Gothard

doi:10.1016/j.jneumeth.2007.11.026

A removable silicone elastomer seal reduces granulation tissue growth and maintains the sterility of recording chambers for primate neurophysiology

Kevin M. Spitler, Katalin M. Gothard

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The maintenance of the sterility of craniotomies for serial acute neurophysiological recordings is exacting and time consuming yet is vital to the health of valuable experimental animals. We have developed a method to seal the craniotomy with surgical grade silicone elastomer (Silastic^®) in a hermetically sealed chamber. Under these conditions the tissues in the craniotomy and the inside surface of the chamber remain unpopulated by bacteria. The silicone elastomer sealant retarded the growth of granulation tissue on the dura and reduced the procedures required to maintain ideal conditions for neurophysiological recordings.

Original language	English (US)
Pages (from-to)	23-26
Number of pages	4
Journal	Journal of Neuroscience Methods
Volume	169
Issue number	1
DOIs	https://doi.org/10.1016/j.jneumeth.2007.11.026
State	Published - Mar 30 2008

Keywords

Craniotomy
Dura mater
Granulation tissue
Monkey
Neurophysiology
Silastic
Silicone elastomer

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.jneumeth.2007.11.026

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title = "A removable silicone elastomer seal reduces granulation tissue growth and maintains the sterility of recording chambers for primate neurophysiology",

abstract = "The maintenance of the sterility of craniotomies for serial acute neurophysiological recordings is exacting and time consuming yet is vital to the health of valuable experimental animals. We have developed a method to seal the craniotomy with surgical grade silicone elastomer (Silastic{\textregistered}) in a hermetically sealed chamber. Under these conditions the tissues in the craniotomy and the inside surface of the chamber remain unpopulated by bacteria. The silicone elastomer sealant retarded the growth of granulation tissue on the dura and reduced the procedures required to maintain ideal conditions for neurophysiological recordings.",

keywords = "Craniotomy, Dura mater, Granulation tissue, Monkey, Neurophysiology, Silastic, Silicone elastomer",

author = "Spitler, {Kevin M.} and Gothard, {Katalin M.}",

note = "Funding Information: We thank P. Zimmerman and K. Brooks for assistance with data collection. This work was supported, in part, by National Institute of Mental Health Grants K01MH-01902A and MH-070836 to K. M. Gothard and National Institute of Mental Health Grant MH072059-01A2 to K. M. Spitler.",

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AU - Spitler, Kevin M.

AU - Gothard, Katalin M.

N1 - Funding Information: We thank P. Zimmerman and K. Brooks for assistance with data collection. This work was supported, in part, by National Institute of Mental Health Grants K01MH-01902A and MH-070836 to K. M. Gothard and National Institute of Mental Health Grant MH072059-01A2 to K. M. Spitler.

PY - 2008/3/30

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N2 - The maintenance of the sterility of craniotomies for serial acute neurophysiological recordings is exacting and time consuming yet is vital to the health of valuable experimental animals. We have developed a method to seal the craniotomy with surgical grade silicone elastomer (Silastic®) in a hermetically sealed chamber. Under these conditions the tissues in the craniotomy and the inside surface of the chamber remain unpopulated by bacteria. The silicone elastomer sealant retarded the growth of granulation tissue on the dura and reduced the procedures required to maintain ideal conditions for neurophysiological recordings.

AB - The maintenance of the sterility of craniotomies for serial acute neurophysiological recordings is exacting and time consuming yet is vital to the health of valuable experimental animals. We have developed a method to seal the craniotomy with surgical grade silicone elastomer (Silastic®) in a hermetically sealed chamber. Under these conditions the tissues in the craniotomy and the inside surface of the chamber remain unpopulated by bacteria. The silicone elastomer sealant retarded the growth of granulation tissue on the dura and reduced the procedures required to maintain ideal conditions for neurophysiological recordings.

KW - Craniotomy

KW - Dura mater

KW - Granulation tissue

KW - Monkey

KW - Neurophysiology

KW - Silastic

KW - Silicone elastomer

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A removable silicone elastomer seal reduces granulation tissue growth and maintains the sterility of recording chambers for primate neurophysiology

Abstract

Keywords

ASJC Scopus subject areas

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