A relationship between substance P receptor and retinal fibers in the rat suprachiasmatic nucleus

Koichi Takatsuji, Emiko Senba, Patrick W. Mantyh, Masaya Tohyama

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The suprachiasmatic nucleus (SCN) in the hypothalamus controls many of the circadian rhythms in mammalian species. In the present study, we investigated the location of substance P receptor (SPR)-containing neurons in the rat SCN, using a specific antibody against SPR, which corresponds to the NK-1 subtype of tachykinin receptors, and also examined the synaptic relationship between SPR-containing neurons and retinal fibers at the ultrastructural level. An SPR-immunoreactive meshwork of labeled somata and dendrites was identified in the SCN. The strongest SPR-immunoreactivity was observed in the dorsal and lateral parts of the SCN. Many labeled somata were identified there and their dendrites protruded ventrally from their somata. A few SPR-immunoreactive somata were observed also in the ventral part of the SCN and within the optic tract. In the SCN of eye-enucleated animals, degenerating retinal fibers were shown to terminate on SPR-immunoreactive dendrites forming asymmetrical axo-dendritic contacts.

Original languageEnglish (US)
Pages (from-to)53-61
Number of pages9
JournalBrain Research
Issue number1-2
StatePublished - Nov 6 1995


  • Immunohistochemistry
  • Rat
  • Retinal fiber
  • Retinohypothalamic projection
  • Substance P receptor
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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