Abstract
A regioselective, mild, convenient, and effective condition is developed for the inclusion of glyoxylic acid as formaldehyde equivalent in the 3CC reaction towards synthesis of 3-aminoalkyl imidazo-azines. In general, formaldehydes do not perform well with Ugi-type multicomponent sequences, and the method reported here is a regioselective and high-yielding one for the HCHO variant of Groebke-Blackburn-Bienaymé reaction.
| Original language | English (US) |
|---|---|
| Article number | S00811ST |
| Pages (from-to) | 1407-1412 |
| Number of pages | 6 |
| Journal | Synlett |
| Issue number | 10 |
| DOIs | |
| State | Published - 2011 |
Keywords
- Groebke-Blackburn-Bienaymé
- aminoimidazoazines
- formaldehyde
- glyoxylic acid
- multicomponent reaction
ASJC Scopus subject areas
- Organic Chemistry
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