A regioselective and high-yielding method for formaldehyde inclusion in the 3CC Groebke-Blackburn-Bienaymé reaction: One-step access to 3-aminoimidazoazines

Anuj Sharma; Hong Yu Li

doi:10.1055/s-0030-1260568

A regioselective and high-yielding method for formaldehyde inclusion in the 3CC Groebke-Blackburn-Bienaymé reaction: One-step access to 3-aminoimidazoazines

Anuj Sharma, Hong Yu Li

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A regioselective, mild, convenient, and effective condition is developed for the inclusion of glyoxylic acid as formaldehyde equivalent in the 3CC reaction towards synthesis of 3-aminoalkyl imidazo-azines. In general, formaldehydes do not perform well with Ugi-type multicomponent sequences, and the method reported here is a regioselective and high-yielding one for the HCHO variant of Groebke-Blackburn-Bienaymé reaction.

Original language	English (US)
Article number	S00811ST
Pages (from-to)	1407-1412
Number of pages	6
Journal	Synlett
Issue number	10
DOIs	https://doi.org/10.1055/s-0030-1260568
State	Published - 2011

Keywords

Groebke-Blackburn-Bienaymé
aminoimidazoazines
formaldehyde
glyoxylic acid
multicomponent reaction

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-0030-1260568

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abstract = "A regioselective, mild, convenient, and effective condition is developed for the inclusion of glyoxylic acid as formaldehyde equivalent in the 3CC reaction towards synthesis of 3-aminoalkyl imidazo-azines. In general, formaldehydes do not perform well with Ugi-type multicomponent sequences, and the method reported here is a regioselective and high-yielding one for the HCHO variant of Groebke-Blackburn-Bienaym{\'e} reaction.",

keywords = "Groebke-Blackburn-Bienaym{\'e}, aminoimidazoazines, formaldehyde, glyoxylic acid, multicomponent reaction",

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AU - Li, Hong Yu

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AB - A regioselective, mild, convenient, and effective condition is developed for the inclusion of glyoxylic acid as formaldehyde equivalent in the 3CC reaction towards synthesis of 3-aminoalkyl imidazo-azines. In general, formaldehydes do not perform well with Ugi-type multicomponent sequences, and the method reported here is a regioselective and high-yielding one for the HCHO variant of Groebke-Blackburn-Bienaymé reaction.

KW - Groebke-Blackburn-Bienaymé

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KW - formaldehyde

KW - glyoxylic acid

KW - multicomponent reaction

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A regioselective and high-yielding method for formaldehyde inclusion in the 3CC Groebke-Blackburn-Bienaymé reaction: One-step access to 3-aminoimidazoazines

Abstract

Keywords

ASJC Scopus subject areas

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