A recyclable fluorous (S)-pyrrolidine sulfonamide promoted direct, highly enantioselective Michael addition of ketones and aldehydes to nitroolefins in water

Liansuo Zu, Jian Wang, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

265 Scopus citations

Abstract

A recycle and reusable fluorous (S)-pyrrolidine sulfonamide organocatalyst has been developed for promoting highly enantio- and diastereoselective Michael addition reactions of ketones and aldehydes with nitroolefins in water. The organocatalyst is conveniently recovered from the reaction mixtures by fluorous solid-phase extraction and can be subsequently reused (up to six cycles) without a significant loss of catalytic activity and stereoselectivity.

Original languageEnglish (US)
Pages (from-to)3077-3079
Number of pages3
JournalOrganic Letters
Volume8
Issue number14
DOIs
StatePublished - Jul 6 2006
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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