A Rapid in Vitro Labeling Index Method for Predicting Response of Human Solid Tumors to Chemotherapy

Michael P. Thirlwell; Robert B Livingston; William K. Murphy; Jacqueline S. Hart

A Rapid in Vitro Labeling Index Method for Predicting Response of Human Solid Tumors to Chemotherapy

Michael P. Thirlwell, Robert B Livingston, William K. Murphy, Jacqueline S. Hart

Cancer Center

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A rapid autoradiographic technique for measuring the [³H]thymidine-labeling index of human solid tumors has been adapted to assess the effect of anticancer drugs in vitro. The drugs tested were present unchanged or as metabolites in serum obtained from patients immediately posttreatment. In 15 patients, the drugs tested in vitro were also given in vivo. Tumor-labeling index fell significantly in 5 of 6 patients who were later found to have objective clinical response. Tumor-labeling index did not change significantly in 8 patients and rose significantly in 1 of 9 patients who lacked clinical response. If confirmed, this in vitro test may prove to be a useful method of predicting responsiveness of human solid cancers to chemotherapeutic agents.

Original language	English (US)
Pages (from-to)	3279-3283
Number of pages	5
Journal	Cancer Research
Volume	36
State	Published - Sep 1976

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "A Rapid in Vitro Labeling Index Method for Predicting Response of Human Solid Tumors to Chemotherapy",

abstract = "A rapid autoradiographic technique for measuring the [3H]thymidine-labeling index of human solid tumors has been adapted to assess the effect of anticancer drugs in vitro. The drugs tested were present unchanged or as metabolites in serum obtained from patients immediately posttreatment. In 15 patients, the drugs tested in vitro were also given in vivo. Tumor-labeling index fell significantly in 5 of 6 patients who were later found to have objective clinical response. Tumor-labeling index did not change significantly in 8 patients and rose significantly in 1 of 9 patients who lacked clinical response. If confirmed, this in vitro test may prove to be a useful method of predicting responsiveness of human solid cancers to chemotherapeutic agents.",

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T1 - A Rapid in Vitro Labeling Index Method for Predicting Response of Human Solid Tumors to Chemotherapy

AU - Thirlwell, Michael P.

AU - Livingston, Robert B

AU - Murphy, William K.

AU - Hart, Jacqueline S.

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AB - A rapid autoradiographic technique for measuring the [3H]thymidine-labeling index of human solid tumors has been adapted to assess the effect of anticancer drugs in vitro. The drugs tested were present unchanged or as metabolites in serum obtained from patients immediately posttreatment. In 15 patients, the drugs tested in vitro were also given in vivo. Tumor-labeling index fell significantly in 5 of 6 patients who were later found to have objective clinical response. Tumor-labeling index did not change significantly in 8 patients and rose significantly in 1 of 9 patients who lacked clinical response. If confirmed, this in vitro test may prove to be a useful method of predicting responsiveness of human solid cancers to chemotherapeutic agents.

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A Rapid in Vitro Labeling Index Method for Predicting Response of Human Solid Tumors to Chemotherapy

Abstract

ASJC Scopus subject areas

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