TY - JOUR
T1 - A randomized phase II study comparing four different interferon therapies in patients with recalcitrant condylomata acuminata
AU - Trizna, Zoltán
AU - Evans, Tanya
AU - Bruce, Suzanne
AU - Hatch, Kenneth
AU - Tyring, Stephen K.
PY - 1998/8
Y1 - 1998/8
N2 - Background: Interferon (IFN) alpha and IFN gamma have synergistic in vitro and in vivo effects and have each been used in the treatment of anogenital condylomata acuminata. Study Goals: To compare the efficacy and safety of regional 3 X 106 U IFN alpha (Group A), 3 x 106 U IFN gamma (Group B), 1.5 x 106 U IFN alpha plus 1.5 x 106 U IFN gamma (Group C), and 3 x 106 U IFN alpha plus 1.5 x 106 U IFN gamma (Group D) in the treatment of recalcitrant anogenital condylomata acuminata. Study Design: Six-week courses of regional IFNs were administered in a randomized, double-blind, multicenter study. Response was assessed as change in the total area affected by condylomata. Results: The treatments of Groups A, B, and C were similarly effective (complete response in 13.6%, 18.5%, and 16.0%, respectively). Group D had the lowest rate of complete response (3.8%), but this combination was the most effective when partial and complete responses were combined (73.0%). Conclusion: Regional IFN is a moderately effective and safe treatment in patients with recalcitrant anogenital condylomata acuminata. Combinations of IFNs alpha and gamma were not superior to IFN monotherapy.
AB - Background: Interferon (IFN) alpha and IFN gamma have synergistic in vitro and in vivo effects and have each been used in the treatment of anogenital condylomata acuminata. Study Goals: To compare the efficacy and safety of regional 3 X 106 U IFN alpha (Group A), 3 x 106 U IFN gamma (Group B), 1.5 x 106 U IFN alpha plus 1.5 x 106 U IFN gamma (Group C), and 3 x 106 U IFN alpha plus 1.5 x 106 U IFN gamma (Group D) in the treatment of recalcitrant anogenital condylomata acuminata. Study Design: Six-week courses of regional IFNs were administered in a randomized, double-blind, multicenter study. Response was assessed as change in the total area affected by condylomata. Results: The treatments of Groups A, B, and C were similarly effective (complete response in 13.6%, 18.5%, and 16.0%, respectively). Group D had the lowest rate of complete response (3.8%), but this combination was the most effective when partial and complete responses were combined (73.0%). Conclusion: Regional IFN is a moderately effective and safe treatment in patients with recalcitrant anogenital condylomata acuminata. Combinations of IFNs alpha and gamma were not superior to IFN monotherapy.
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U2 - 10.1097/00007435-199808000-00007
DO - 10.1097/00007435-199808000-00007
M3 - Article
C2 - 9713916
AN - SCOPUS:0031870948
VL - 25
SP - 361
EP - 365
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
SN - 0148-5717
IS - 7
ER -