A putative role for apelin in the etiology of obesity

Srujana Rayalam; Mary Anne Della-Fera; Paul A. Krieg; Christopher M. Cox; Allan Robins; Clifton A. Baile

doi:10.1016/j.bbrc.2008.02.008

A putative role for apelin in the etiology of obesity

Srujana Rayalam, Mary Anne Della-Fera, Paul A. Krieg, Christopher M. Cox, Allan Robins, Clifton A. Baile

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.

Original language	English (US)
Pages (from-to)	815-819
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	368
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2008.02.008
State	Published - Apr 11 2008
Externally published	Yes

Keywords

APJ receptor
Adipose tissue
Adiposity
Angiogenesis
Apelin
Endothelial cells
Obesity

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2008.02.008

Cite this

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title = "A putative role for apelin in the etiology of obesity",

abstract = "Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.",

keywords = "APJ receptor, Adipose tissue, Adiposity, Angiogenesis, Apelin, Endothelial cells, Obesity",

author = "Srujana Rayalam and Della-Fera, {Mary Anne} and Krieg, {Paul A.} and Cox, {Christopher M.} and Allan Robins and Baile, {Clifton A.}",

note = "Funding Information: This work was supported, in part, by the Georgia Research Alliance Eminent Scholar endowment held by CAB and grants from the Georgia Research Alliance.",

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T1 - A putative role for apelin in the etiology of obesity

AU - Rayalam, Srujana

AU - Della-Fera, Mary Anne

AU - Krieg, Paul A.

AU - Cox, Christopher M.

AU - Robins, Allan

AU - Baile, Clifton A.

N1 - Funding Information: This work was supported, in part, by the Georgia Research Alliance Eminent Scholar endowment held by CAB and grants from the Georgia Research Alliance.

PY - 2008/4/11

Y1 - 2008/4/11

N2 - Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.

AB - Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.

KW - APJ receptor

KW - Adipose tissue

KW - Adiposity

KW - Angiogenesis

KW - Apelin

KW - Endothelial cells

KW - Obesity

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JO - Biochemical and Biophysical Research Communications

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A putative role for apelin in the etiology of obesity

Abstract

Keywords

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