TY - JOUR
T1 - A porohyperelastic finite element model of the eye
T2 - the influence of stiffness and permeability on intraocular pressure and optic nerve head biomechanics
AU - Ayyalasomayajula, Avinash
AU - Park, Robert I.
AU - Simon, Bruce R.
AU - Vande Geest, Jonathan P.
N1 - Funding Information:
Funding for this work was provided by the NIH [grant number 1R01EY020890] to JPVG, partial support was provided by the University of Arizona TRIF Fellowship Program to AA, and is based on a work partially supported by Award No. KUK-C1-013- 04, made by King Abdullah University of Science and Technology.
Publisher Copyright:
© 2015 Taylor & Francis.
PY - 2016/4/25
Y1 - 2016/4/25
N2 - Progressively deteriorating visual field is a characteristic feature of primary open-angle glaucoma (POAG), and the biomechanics of optic nerve head (ONH) is believed to be important in its onset. We used porohyperelasticity to model the complex porous behavior of ocular tissues to better understand the effect variations in ocular material properties can have on ONH biomechanics. An axisymmetric model of the human eye was constructed to parametrically study how changes in the permeabilities of retina–Bruch's–choroid complex (Formula presented.) , sclera (Formula presented.) , uveoscleral pathway (Formula presented.) , and trabecular meshwork (Formula presented.) as well as how changes in the stiffness of the lamina cribrosa (LC) and sclera affect IOP, LC strains, and translaminar interstitial pressure gradients (TLIPG). Decreasing (Formula presented.) from 5 × 10− 12 to 5 × 10− 13 m/s increased IOP and LC strains by 17%, and TLIPG by 21%. LC strains increased by 13% and 9% when the scleral and LC moduli were decreased by 48% and 50%, respectively. In addition to the trabecular meshwork and uveoscleral pathway, the retina–Bruch's–choroid complex had an important effect on IOP, LC strains, and TLIPG. Changes in (Formula presented.) and scleral modulus resulted in nonlinear changes in the IOP, and LC strains especially at the lowest (Formula presented.) and (Formula presented.). This study demonstrates that porohyperelastic modeling provides a novel method for computationally studying the biomechanical environment of the ONH. Porohyperelastic simulations of ocular tissues may help provide further insight into the complex biomechanical environment of posterior ocular tissues in POAG.
AB - Progressively deteriorating visual field is a characteristic feature of primary open-angle glaucoma (POAG), and the biomechanics of optic nerve head (ONH) is believed to be important in its onset. We used porohyperelasticity to model the complex porous behavior of ocular tissues to better understand the effect variations in ocular material properties can have on ONH biomechanics. An axisymmetric model of the human eye was constructed to parametrically study how changes in the permeabilities of retina–Bruch's–choroid complex (Formula presented.) , sclera (Formula presented.) , uveoscleral pathway (Formula presented.) , and trabecular meshwork (Formula presented.) as well as how changes in the stiffness of the lamina cribrosa (LC) and sclera affect IOP, LC strains, and translaminar interstitial pressure gradients (TLIPG). Decreasing (Formula presented.) from 5 × 10− 12 to 5 × 10− 13 m/s increased IOP and LC strains by 17%, and TLIPG by 21%. LC strains increased by 13% and 9% when the scleral and LC moduli were decreased by 48% and 50%, respectively. In addition to the trabecular meshwork and uveoscleral pathway, the retina–Bruch's–choroid complex had an important effect on IOP, LC strains, and TLIPG. Changes in (Formula presented.) and scleral modulus resulted in nonlinear changes in the IOP, and LC strains especially at the lowest (Formula presented.) and (Formula presented.). This study demonstrates that porohyperelastic modeling provides a novel method for computationally studying the biomechanical environment of the ONH. Porohyperelastic simulations of ocular tissues may help provide further insight into the complex biomechanical environment of posterior ocular tissues in POAG.
KW - choroid
KW - finite element analysis
KW - ocular biomechanics
KW - permeability
KW - porohyperelasticity
KW - translaminar pressure gradients
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U2 - 10.1080/10255842.2015.1052417
DO - 10.1080/10255842.2015.1052417
M3 - Article
C2 - 26195024
AN - SCOPUS:84955642251
SN - 1025-5842
VL - 19
SP - 591
EP - 602
JO - Computer Methods in Biomechanics and Biomedical Engineering
JF - Computer Methods in Biomechanics and Biomedical Engineering
IS - 6
ER -