A point mutation in the c-myc locus of a burkitt lymphoma abolishes binding of a nuclear protein

Maria Zajac-Kaye, Edward P. Gelmann, David Levens

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

A 20-base pair region in the first intron of the human c-myc gene was identified as the binding site of a nuclear protein. This binding site is mutated hi five out of seven Burkitt lymphomas sequenced to date. To investigate the protein-recognition region in greater detail, the abnormal c-myc allele from a Burkitt lymphoma line (PA682) that carries a t(8;22) chromosomal translocation was used. A point mutation in the binding region of the PA682 c-myc DNA abolished binding of this nuclear protein. This protein may be an important factor for control of c-myc expression, and mutations in its recognition sequence may be associated with c-myc activation in many cases of Burkitt lymphoma.

Original languageEnglish (US)
Pages (from-to)1776-1780
Number of pages5
JournalScience
Volume240
Issue number4860
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • General

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