A pilot sweet cherry feeding study in overweight men: Tolerance, safety, and anthocyanin exposure

Ashley J. Vargas; Lindsey N. McDonnell; Zhongfa Liu; Betsy C. Wertheim; Cynthia A. Thomson; Patricia A. Thompson

doi:10.1016/j.jff.2014.08.005

A pilot sweet cherry feeding study in overweight men: Tolerance, safety, and anthocyanin exposure

Ashley J. Vargas, Lindsey N. McDonnell, Zhongfa Liu, Betsy C. Wertheim, Cynthia A. Thomson, Patricia A. Thompson

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Sweet cherries are rich in bioactive anthocyanins (ACN) and thus are considered a functional food. Yet, tolerance to and bioavailability of a significant daily dose of cherries has not been evaluated in humans. This pilot study aimed to assess compliance, tolerance, safety, and change in circulating/excreted ACNs due to daily consumption of sweet cherries. Change in bowel habits, quality of life, urinary/circulating concentration ACNs, and inflammatory biomarkers were measured in overweight, older men (n = 37) before and after daily consumption of three cups of sweet cherries for 4 weeks. Cherry fruit ACN content was also measured. Tolerance to intervention was high in this study. An increase in several plasma/urine ACNs was observed, but did not correlate with the amount of ACN measured in the fruits. No significant changes in inflammatory biomarkers were observed. This intervention was feasible and increased anthocyanin exposure in overweight men.

Original language	English (US)
Pages (from-to)	500-508
Number of pages	9
Journal	Journal of Functional Foods
Volume	11
Issue number	C
DOIs	https://doi.org/10.1016/j.jff.2014.08.005
State	Published - 2014

Keywords

Anthocyanin
Biological marker
Cherry
Food safety
Prunus
Tolerance

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

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10.1016/j.jff.2014.08.005

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title = "A pilot sweet cherry feeding study in overweight men: Tolerance, safety, and anthocyanin exposure",

abstract = "Sweet cherries are rich in bioactive anthocyanins (ACN) and thus are considered a functional food. Yet, tolerance to and bioavailability of a significant daily dose of cherries has not been evaluated in humans. This pilot study aimed to assess compliance, tolerance, safety, and change in circulating/excreted ACNs due to daily consumption of sweet cherries. Change in bowel habits, quality of life, urinary/circulating concentration ACNs, and inflammatory biomarkers were measured in overweight, older men (n = 37) before and after daily consumption of three cups of sweet cherries for 4 weeks. Cherry fruit ACN content was also measured. Tolerance to intervention was high in this study. An increase in several plasma/urine ACNs was observed, but did not correlate with the amount of ACN measured in the fruits. No significant changes in inflammatory biomarkers were observed. This intervention was feasible and increased anthocyanin exposure in overweight men.",

keywords = "Anthocyanin, Biological marker, Cherry, Food safety, Prunus, Tolerance",

author = "Vargas, {Ashley J.} and McDonnell, {Lindsey N.} and Zhongfa Liu and Wertheim, {Betsy C.} and Thomson, {Cynthia A.} and Thompson, {Patricia A.}",

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year = "2014",

doi = "10.1016/j.jff.2014.08.005",

language = "English (US)",

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T2 - Tolerance, safety, and anthocyanin exposure

AU - Vargas, Ashley J.

AU - McDonnell, Lindsey N.

AU - Liu, Zhongfa

AU - Wertheim, Betsy C.

AU - Thomson, Cynthia A.

AU - Thompson, Patricia A.

PY - 2014

Y1 - 2014

N2 - Sweet cherries are rich in bioactive anthocyanins (ACN) and thus are considered a functional food. Yet, tolerance to and bioavailability of a significant daily dose of cherries has not been evaluated in humans. This pilot study aimed to assess compliance, tolerance, safety, and change in circulating/excreted ACNs due to daily consumption of sweet cherries. Change in bowel habits, quality of life, urinary/circulating concentration ACNs, and inflammatory biomarkers were measured in overweight, older men (n = 37) before and after daily consumption of three cups of sweet cherries for 4 weeks. Cherry fruit ACN content was also measured. Tolerance to intervention was high in this study. An increase in several plasma/urine ACNs was observed, but did not correlate with the amount of ACN measured in the fruits. No significant changes in inflammatory biomarkers were observed. This intervention was feasible and increased anthocyanin exposure in overweight men.

AB - Sweet cherries are rich in bioactive anthocyanins (ACN) and thus are considered a functional food. Yet, tolerance to and bioavailability of a significant daily dose of cherries has not been evaluated in humans. This pilot study aimed to assess compliance, tolerance, safety, and change in circulating/excreted ACNs due to daily consumption of sweet cherries. Change in bowel habits, quality of life, urinary/circulating concentration ACNs, and inflammatory biomarkers were measured in overweight, older men (n = 37) before and after daily consumption of three cups of sweet cherries for 4 weeks. Cherry fruit ACN content was also measured. Tolerance to intervention was high in this study. An increase in several plasma/urine ACNs was observed, but did not correlate with the amount of ACN measured in the fruits. No significant changes in inflammatory biomarkers were observed. This intervention was feasible and increased anthocyanin exposure in overweight men.

KW - Anthocyanin

KW - Biological marker

KW - Cherry

KW - Food safety

KW - Prunus

KW - Tolerance

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JO - Journal of Functional Foods

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IS - C

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A pilot sweet cherry feeding study in overweight men: Tolerance, safety, and anthocyanin exposure

Abstract

Keywords

ASJC Scopus subject areas

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