A pilot study examining short-term changes in bone mineral density among class 3 obese users of depot-medroxyprogesterone acetate

Penina Segall-Gutierrez, Reshem Agarwal, Marshall Ge, Claudia Lopez, Gerson Hernandez, Frank Z. Stanczyk

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective To examine changes in lumbar spine-bone mineral density (LS-BMD) among normal weight (body mass index [BMI] = 18.5-24.9 kg/m2), Class 1-2 obese (BMI = 30-39.9 kg/m2), and Class 3 obese (BMI ≥ 40 kg/m2) women utilising depot-medroxyprogesterone acetate (DMPA). Methods Five normal-weight, five Class 1-2 obese, and five Class 3 obese women received subcutaneous injections of DMPA-SC at baseline and 12 weeks later. Dual Energy X-ray Absorptiometry (DEXA) scans were performed at baseline and 18 weeks after the first injection for determination of LS-BMD and analysis of fat content. Bimonthly oestradiol (E2) levels were measured by immunoassay methods for 26 weeks. Results There were no significant demographic or LS-BMD differences among the three BMI groups. Significant differences at baseline were as expected among the three groups with respect to BMI and associated parameters (mean % total body fat, absolute fat, and weight). When used as their own controls, significant changes in LS-BMD, % body fat and absolute fat determined by DEXA occurred among all three BMI strata. Class 1-2 obese and Class 3 obese women were more likely to experience E2 fluctuations, but short-term changes in LS-BMD were similar. Conclusions DMPA-SC administration affects L-spine bone health similarly regardless of BMI status.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalEuropean Journal of Contraception and Reproductive Health Care
Volume18
Issue number3
DOIs
StatePublished - Jun 2013
Externally publishedYes

Keywords

  • Bone mineral density
  • Class 3 obese
  • Contraception
  • Depot-medroxyprogesterone acetate
  • Dual Energy X-ray Absorptiometry
  • Injectable
  • Obese

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Pharmacology (medical)

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