A PET-based fluorescent probe for monitoring labile Fe(ii) pools in macrophage activations and ferroptosis

Wanjin Xing, Hang Xu, Huijuan Ma, Syed Ali Abbas Abedi, Shanshan Wang, Xingchen Zhang, Xiaogang Liu, Huan Xu, Wei Wang, Kaiyan Lou

Research output: Contribution to journalArticlepeer-review

Abstract

A fluorescent probe (COU-LIP-1) for monitoring labile Fe(ii) pools (LIP) with high selectivity and sensitivity was developed utilizing coumarin 343 as the fluorophore and 3-nitrophenylazanyl ester as both the reactive group and the fluorescence quenching group. Fe(ii)-induced reductive cleavage of the N-O bond results in a turn-on response via a photo-induced photon transfer (PET) mechanism. The probe was applied for monitoring labile iron(ii) changes in M1 and M2a macrophage activations and also erastin-induced ferroptosis, providing a powerful tool for selectively sensing LIP under both physiological and stressed conditions.

Original languageEnglish (US)
Pages (from-to)2979-2982
Number of pages4
JournalChemical Communications
Volume58
Issue number18
DOIs
StatePublished - Mar 4 2022

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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