A novel strategy toward [6,5]-bicyclic β-turn dipeptide

Xuyuan Gu, Xuejun Tang, Scott Cowell, Jinfa Ying, Victor J. Hruby

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


A novel strategy toward the syntheses of [6,5]-bicyclic β-turn dipeptides has been developed starting from δ,ε-unsaturated amino acids. This is the first example showing that this scaffold can be synthesized from a terminal alkene using a trifluoroacetyl protected amino acid. Both enantiomers of the δ,ε-unsaturated amino acid were synthesized by a modified method using Ni(II)-complexes.

Original languageEnglish (US)
Pages (from-to)6669-6672
Number of pages4
JournalTetrahedron Letters
Issue number37
StatePublished - Sep 9 2002


  • Bicyclic turned dipeptide
  • Ni(II)-complexes
  • β-turn mimetic
  • δ,ε-unsaturated amino acids

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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