A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations

Muhammad Ayaz; Justin Dietrich; Christopher Hulme

doi:10.1016/j.tetlet.2011.06.115

A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations

Muhammad Ayaz, Justin Dietrich, Christopher Hulme

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields.

Original language	English (US)
Pages (from-to)	4821-4823
Number of pages	3
Journal	Tetrahedron Letters
Volume	52
Issue number	38
DOIs	https://doi.org/10.1016/j.tetlet.2011.06.115
State	Published - Sep 21 2011

Keywords

Intramolecular cyclization
Microwave
Multicomponent reaction
Petasis reaction
Quinoxaline

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2011.06.115

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abstract = "This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields.",

keywords = "Intramolecular cyclization, Microwave, Multicomponent reaction, Petasis reaction, Quinoxaline",

author = "Muhammad Ayaz and Justin Dietrich and Christopher Hulme",

note = "Funding Information: We would like to thank the Office of the Director, NIH, and the National Institute of Mental Health for funding ( 1RC2MH090878-01 ).",

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AU - Ayaz, Muhammad

AU - Dietrich, Justin

AU - Hulme, Christopher

N1 - Funding Information: We would like to thank the Office of the Director, NIH, and the National Institute of Mental Health for funding ( 1RC2MH090878-01 ).

PY - 2011/9/21

Y1 - 2011/9/21

N2 - This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields.

AB - This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields.

KW - Intramolecular cyclization

KW - Microwave

KW - Multicomponent reaction

KW - Petasis reaction

KW - Quinoxaline

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 38

ER -

A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations

Abstract

Keywords

ASJC Scopus subject areas

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