A novel pyrrolidine imide catalyzed direct formation of α,β-unsaturated ketones from unmodified ketones and aldehydes

Wei Wang; Yujiang Mei; Hao Li; Jian Wang

doi:10.1021/ol047630g

A novel pyrrolidine imide catalyzed direct formation of α,β-unsaturated ketones from unmodified ketones and aldehydes

Wei Wang
, Yujiang Mei
, Hao Li
, Jian Wang

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

(Chemical Equation Presented) A method for direct, stereoselective preparation of (E)-α,β-unsaturated ketones from ketones and aldehydes, promoted by a novel pyrrolidine imide organocatalyst, has been developed in moderate to high yields. Unlike the Claisen-Schmidt condensation and Lewis acid catalyzed tandem aldol-dehydration processes, this method provides mild reaction conditions to access α,β-unsaturated ketones from simple, unmodified ketones.

Original language	English (US)
Pages (from-to)	601-604
Number of pages	4
Journal	Organic Letters
Volume	7
Issue number	4
DOIs	https://doi.org/10.1021/ol047630g
State	Published - Feb 17 2005
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol047630g

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abstract = "(Chemical Equation Presented) A method for direct, stereoselective preparation of (E)-α,β-unsaturated ketones from ketones and aldehydes, promoted by a novel pyrrolidine imide organocatalyst, has been developed in moderate to high yields. Unlike the Claisen-Schmidt condensation and Lewis acid catalyzed tandem aldol-dehydration processes, this method provides mild reaction conditions to access α,β-unsaturated ketones from simple, unmodified ketones.",

author = "Wei Wang and Yujiang Mei and Hao Li and Jian Wang",

year = "2005",

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doi = "10.1021/ol047630g",

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T1 - A novel pyrrolidine imide catalyzed direct formation of α,β-unsaturated ketones from unmodified ketones and aldehydes

AU - Wang, Wei

AU - Mei, Yujiang

AU - Li, Hao

AU - Wang, Jian

PY - 2005/2/17

Y1 - 2005/2/17

N2 - (Chemical Equation Presented) A method for direct, stereoselective preparation of (E)-α,β-unsaturated ketones from ketones and aldehydes, promoted by a novel pyrrolidine imide organocatalyst, has been developed in moderate to high yields. Unlike the Claisen-Schmidt condensation and Lewis acid catalyzed tandem aldol-dehydration processes, this method provides mild reaction conditions to access α,β-unsaturated ketones from simple, unmodified ketones.

AB - (Chemical Equation Presented) A method for direct, stereoselective preparation of (E)-α,β-unsaturated ketones from ketones and aldehydes, promoted by a novel pyrrolidine imide organocatalyst, has been developed in moderate to high yields. Unlike the Claisen-Schmidt condensation and Lewis acid catalyzed tandem aldol-dehydration processes, this method provides mild reaction conditions to access α,β-unsaturated ketones from simple, unmodified ketones.

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U2 - 10.1021/ol047630g

DO - 10.1021/ol047630g

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JO - Organic Letters

JF - Organic Letters

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ER -

A novel pyrrolidine imide catalyzed direct formation of α,β-unsaturated ketones from unmodified ketones and aldehydes

Abstract

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