TY - GEN
T1 - A novel drug delivery device for orthopedic applications
AU - Song, Shang
AU - Chen, Yupeng
AU - Fenniri, Hicham
AU - Webster, Thomas J.
PY - 2010
Y1 - 2010
N2 - Rosette nanotubes (RNTs) are novel, biomimetic, synthetic, self-assembled drug delivery agents. Because of base stacking and hydrophobic interactions, the RNT hollow-tube structure can be used for incorporating drugs. Another advantage of using RNTs is their ability to be injected and become solid at body temperatures for orthopedic applications without the use of any external stimuli (such as UV light or crosslinking agents). The nano-features of RNTs create a favorable, biologically-inspired, cellular environment. In this study, methods to incorporate DEX (DEX, a bone growth promoting drug) into RNTs were investigated. The drug-loaded RNTs were characterized using Nuclear Magnetic Resonance (NMR), Diffusion Ordered Spectroscopy (DOSY) and Ultraviolet-visible Spectroscopy (UV-vis). Results showed that small molecular drugs with hydrophobic aromatic rings were incorporated into RNTs. Subsequent drug release experiments demonstrated that DEX was released from the RNTs and had a positive impact on osteoblast functions. Importantly, compared to other drug carriers, RNTs increased the total drug loading and was the highest when DEX was incorporated during the RNT self-assembly process. Thus, this study offered a novel drug delivery device that itself is bioactive and can be used to deliver a variety of drugs for various orthopedic applications.
AB - Rosette nanotubes (RNTs) are novel, biomimetic, synthetic, self-assembled drug delivery agents. Because of base stacking and hydrophobic interactions, the RNT hollow-tube structure can be used for incorporating drugs. Another advantage of using RNTs is their ability to be injected and become solid at body temperatures for orthopedic applications without the use of any external stimuli (such as UV light or crosslinking agents). The nano-features of RNTs create a favorable, biologically-inspired, cellular environment. In this study, methods to incorporate DEX (DEX, a bone growth promoting drug) into RNTs were investigated. The drug-loaded RNTs were characterized using Nuclear Magnetic Resonance (NMR), Diffusion Ordered Spectroscopy (DOSY) and Ultraviolet-visible Spectroscopy (UV-vis). Results showed that small molecular drugs with hydrophobic aromatic rings were incorporated into RNTs. Subsequent drug release experiments demonstrated that DEX was released from the RNTs and had a positive impact on osteoblast functions. Importantly, compared to other drug carriers, RNTs increased the total drug loading and was the highest when DEX was incorporated during the RNT self-assembly process. Thus, this study offered a novel drug delivery device that itself is bioactive and can be used to deliver a variety of drugs for various orthopedic applications.
UR - https://www.scopus.com/pages/publications/77953080673
UR - https://www.scopus.com/pages/publications/77953080673#tab=citedBy
U2 - 10.1109/NEBC.2010.5458247
DO - 10.1109/NEBC.2010.5458247
M3 - Conference contribution
AN - SCOPUS:77953080673
SN - 9781424468799
T3 - Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
BT - Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
T2 - 36th Annual Northeast Bioengineering Conference, NEBEC 2010
Y2 - 26 March 2010 through 28 March 2010
ER -