A new technology for terahertz imaging in breast cancer margin determination

Sigfrid Yngvesson, Benjamin St. Peter, Paul Siqueira, Patrick Kelly, Stephen Glick, Andrew Karellas

Research output: Chapter in Book/Report/Conference proceedingConference contribution


In this paper we describe a project for designing, developing and translating a THz imaging device for monitoring margins from extracted tissue during surgical breast cancer conservation procedures. In this application, the reflective and transmission properties of extracted tissue are monitored, in near real-time using a fine-beam THz signal which is sensitive to the presence of liquid and bound water content. In this way, it is intended that the extracted tissue will be studied in the operating theatre to determine during surgery, whether or not the region of malignant tissue has been fully excised from the patient. In the early stages of this project, we are determining to what degree an existing THz system at the University of Massachusetts (UMass) in Amherst is able to differentiate between breast carcinoma, normal fibroglandular and adipose tissues. This is achieved through close collaboration with a surgical and radiological team at the UMass-Worcester medical school and involves post-surgical recovered tissues. As part of this work, we are describing the system, measurement methodology, and first results that were obtained to calibrate the imaging system.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2011
Subtitle of host publicationPhysics of Medical Imaging
StatePublished - 2011
EventMedical Imaging 2011: Physics of Medical Imaging - Lake Buena Vista, FL, United States
Duration: Feb 13 2011Feb 17 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2011: Physics of Medical Imaging
Country/TerritoryUnited States
CityLake Buena Vista, FL

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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