A new role for PGRP-S (Tag7) in immune defense: Lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1

E. A. Dukhanina; T. I. Lukyanova; E. A. Romanova; V. Guerriero; N. V. Gnuchev; G. P. Georgiev; D. V. Yashin; L. P. Sashchenko

doi:10.1080/15384101.2015.1104440

A new role for PGRP-S (Tag7) in immune defense: Lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1

E. A. Dukhanina, T. I. Lukyanova, E. A. Romanova, V. Guerriero, N. V. Gnuchev, G. P. Georgiev, D. V. Yashin, L. P. Sashchenko

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7–Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4⁺ and CD8⁺ lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response.

Original language	English (US)
Pages (from-to)	3635-3643
Number of pages	9
Journal	Cell Cycle
Volume	14
Issue number	22
DOIs	https://doi.org/10.1080/15384101.2015.1104440
State	Published - 2015

Keywords

Chemotaxis
Human lymphocytes
Mts1
NK cells
Tag7
Tag7-Mts1 complex

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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10.1080/15384101.2015.1104440

Cite this

@article{b9d8e9ce90e74720b2f1d825f1e25756,

title = "A new role for PGRP-S (Tag7) in immune defense: Lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1",

abstract = "PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7–Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4+ and CD8+ lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response.",

keywords = "Chemotaxis, Human lymphocytes, Mts1, NK cells, Tag7, Tag7-Mts1 complex",

author = "Dukhanina, {E. A.} and Lukyanova, {T. I.} and Romanova, {E. A.} and V. Guerriero and Gnuchev, {N. V.} and Georgiev, {G. P.} and Yashin, {D. V.} and Sashchenko, {L. P.}",

note = "Funding Information: This work was supported by Russian Science Foundation grant N 15–14–00031 (paragraphs 3, 4, 5 of Results), RAS Program for Molecular and Cellular Biology (paragraphs 1, 2 of Results). Publisher Copyright: {\textcopyright} 2015 Taylor & Francis Group, LLC.",

year = "2015",

doi = "10.1080/15384101.2015.1104440",

language = "English (US)",

volume = "14",

pages = "3635--3643",

journal = "Cell Cycle",

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publisher = "Landes Bioscience",

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T1 - A new role for PGRP-S (Tag7) in immune defense

T2 - Lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1

AU - Dukhanina, E. A.

AU - Lukyanova, T. I.

AU - Romanova, E. A.

AU - Guerriero, V.

AU - Gnuchev, N. V.

AU - Georgiev, G. P.

AU - Yashin, D. V.

AU - Sashchenko, L. P.

N1 - Funding Information: This work was supported by Russian Science Foundation grant N 15–14–00031 (paragraphs 3, 4, 5 of Results), RAS Program for Molecular and Cellular Biology (paragraphs 1, 2 of Results). Publisher Copyright: © 2015 Taylor & Francis Group, LLC.

PY - 2015

Y1 - 2015

N2 - PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7–Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4+ and CD8+ lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response.

AB - PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7–Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4+ and CD8+ lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response.

KW - Chemotaxis

KW - Human lymphocytes

KW - Mts1

KW - NK cells

KW - Tag7

KW - Tag7-Mts1 complex

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A new role for PGRP-S (Tag7) in immune defense: Lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1

Abstract

Keywords

ASJC Scopus subject areas

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