TY - JOUR
T1 - A new perspective on oxidation of DNA repair proteins and cancer
AU - Alnajjar, Khadijeh S.
AU - Sweasy, Joann B.
N1 - Funding Information:
This work was supported by the National Cancer Institute [ CA080830 ].
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/4
Y1 - 2019/4
N2 - Reactive oxygen and nitrogen species (RONS) are formed as byproducts of many endogenous cellular processes, in response to infections, and upon exposure to various environmental factors. An increase in RONS can saturate the antioxidation system and leads to oxidative stress. Consequently, macromolecules are targeted for oxidative modifications, including DNA and protein. The oxidation of DNA, which leads to base modification and formation of abasic sites along with single and double strand breaks, has been extensively investigated. Protein oxidation is often neglected and is only recently being recognized as an important regulatory mechanism of various DNA repair proteins. This is a review of the current state of research on the regulation of DNA repair by protein oxidation with emphasis on the correlation between inflammation and cancer.
AB - Reactive oxygen and nitrogen species (RONS) are formed as byproducts of many endogenous cellular processes, in response to infections, and upon exposure to various environmental factors. An increase in RONS can saturate the antioxidation system and leads to oxidative stress. Consequently, macromolecules are targeted for oxidative modifications, including DNA and protein. The oxidation of DNA, which leads to base modification and formation of abasic sites along with single and double strand breaks, has been extensively investigated. Protein oxidation is often neglected and is only recently being recognized as an important regulatory mechanism of various DNA repair proteins. This is a review of the current state of research on the regulation of DNA repair by protein oxidation with emphasis on the correlation between inflammation and cancer.
KW - Base excision repair
KW - DNA damage
KW - Double strand break repair
KW - Oxidation of DNA repair proteins
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85061896517&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061896517&partnerID=8YFLogxK
U2 - 10.1016/j.dnarep.2019.02.006
DO - 10.1016/j.dnarep.2019.02.006
M3 - Review article
C2 - 30818170
AN - SCOPUS:85061896517
SN - 1568-7864
VL - 76
SP - 60
EP - 69
JO - DNA Repair
JF - DNA Repair
ER -