A new nonionic macrocyclic gadolinium(III) chelate as a potential magnetic-resonance-imaging contrast agent

Michiko B. Inoue; Paul Oram; Motomichi Inoue; Quintus Fernando; Andrew L. Alexander; Evan C. Unger

doi:10.1016/0730-725X(94)92536-4

A new nonionic macrocyclic gadolinium(III) chelate as a potential magnetic-resonance-imaging contrast agent

Michiko B. Inoue, Paul Oram, Motomichi Inoue, Quintus Fernando, Andrew L. Alexander, Evan C. Unger

Cancer Center

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A new Gd^III complex of a 17-membered macrocycle with three pendant carboxymethyl groups has been synthesized; the ligand has been obtained in a single step from diethylenetriaminepentaacetic dianhydride (pentetic dianhydride) and 1,4-butanediamine (putrescine). An X-ray crystal analysis has shown that the complex is a nonionic metal chelate with a coordinated water molecule. The near-zero electrical conductivity, 1 Ω^-1 cm² mol^-1, of a 1 mM solution indicated that the metal chelate is essentially undissociated. The NMR T₁ relaxivity is 2.5 s^-1 mM^-1 at a resonance field of 64 MHz, and 3.4 s^-1 mM^-1 at 250 MHz. This new Gd^III complex is a potentially important magnetic resonance imaging contrast agent.

Original language	English (US)
Pages (from-to)	429-432
Number of pages	4
Journal	Magnetic Resonance Imaging
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/0730-725X(94)92536-4
State	Published - 1994

Keywords

MRI contrast agent
Nonionic gadolinium chelate

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

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10.1016/0730-725X(94)92536-4

Cite this

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title = "A new nonionic macrocyclic gadolinium(III) chelate as a potential magnetic-resonance-imaging contrast agent",

abstract = "A new GdIII complex of a 17-membered macrocycle with three pendant carboxymethyl groups has been synthesized; the ligand has been obtained in a single step from diethylenetriaminepentaacetic dianhydride (pentetic dianhydride) and 1,4-butanediamine (putrescine). An X-ray crystal analysis has shown that the complex is a nonionic metal chelate with a coordinated water molecule. The near-zero electrical conductivity, 1 Ω-1 cm2 mol-1, of a 1 mM solution indicated that the metal chelate is essentially undissociated. The NMR T1 relaxivity is 2.5 s-1 mM-1 at a resonance field of 64 MHz, and 3.4 s-1 mM-1 at 250 MHz. This new GdIII complex is a potentially important magnetic resonance imaging contrast agent.",

keywords = "MRI contrast agent, Nonionic gadolinium chelate",

author = "Inoue, {Michiko B.} and Paul Oram and Motomichi Inoue and Quintus Fernando and Alexander, {Andrew L.} and Unger, {Evan C.}",

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T1 - A new nonionic macrocyclic gadolinium(III) chelate as a potential magnetic-resonance-imaging contrast agent

AU - Inoue, Michiko B.

AU - Oram, Paul

AU - Inoue, Motomichi

AU - Fernando, Quintus

AU - Alexander, Andrew L.

AU - Unger, Evan C.

PY - 1994

Y1 - 1994

N2 - A new GdIII complex of a 17-membered macrocycle with three pendant carboxymethyl groups has been synthesized; the ligand has been obtained in a single step from diethylenetriaminepentaacetic dianhydride (pentetic dianhydride) and 1,4-butanediamine (putrescine). An X-ray crystal analysis has shown that the complex is a nonionic metal chelate with a coordinated water molecule. The near-zero electrical conductivity, 1 Ω-1 cm2 mol-1, of a 1 mM solution indicated that the metal chelate is essentially undissociated. The NMR T1 relaxivity is 2.5 s-1 mM-1 at a resonance field of 64 MHz, and 3.4 s-1 mM-1 at 250 MHz. This new GdIII complex is a potentially important magnetic resonance imaging contrast agent.

AB - A new GdIII complex of a 17-membered macrocycle with three pendant carboxymethyl groups has been synthesized; the ligand has been obtained in a single step from diethylenetriaminepentaacetic dianhydride (pentetic dianhydride) and 1,4-butanediamine (putrescine). An X-ray crystal analysis has shown that the complex is a nonionic metal chelate with a coordinated water molecule. The near-zero electrical conductivity, 1 Ω-1 cm2 mol-1, of a 1 mM solution indicated that the metal chelate is essentially undissociated. The NMR T1 relaxivity is 2.5 s-1 mM-1 at a resonance field of 64 MHz, and 3.4 s-1 mM-1 at 250 MHz. This new GdIII complex is a potentially important magnetic resonance imaging contrast agent.

KW - MRI contrast agent

KW - Nonionic gadolinium chelate

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ER -

A new nonionic macrocyclic gadolinium(III) chelate as a potential magnetic-resonance-imaging contrast agent

Abstract

Keywords

ASJC Scopus subject areas

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CCDC 119888: Experimental Crystal Structure Determination

Cite this

A new nonionic macrocyclic gadolinium(III) chelate as a potential magnetic-resonance-imaging contrast agent

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Datasets

CCDC 119888: Experimental Crystal Structure Determination

Cite this