A New Machine for Automated Solid Phase Peptide Synthesis

Victor J. Hruby, Leon E. Barstow, Theo Linhart

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


A versatile, fail-safe, and simple machine for automated solid phase peptide synthesis was designed and constructed. A dual programming scheme was used. The variable operations such as kind and quantity of solvent or reagent, reaction or wash times, and other variables, are controlled by a Drum Programmer. The repetitive operations needed to get the solvent or reagent into and out of the reaction vessel are controlled by a Card Programmer. A number of failsafe devices weee built into the machine to shut it off if electrical or mechanical failures occur. The operation is also monitored with a strip chart recorder which gives a permanent record of a synthesis. The machine can be operated in both automatic and manual modes.

Original languageEnglish (US)
Pages (from-to)343-350
Number of pages8
JournalAnalytical Chemistry
Issue number2
StatePublished - Feb 1 1972

ASJC Scopus subject areas

  • Analytical Chemistry


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