A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-l-proline with aldehydes

Zhiqin Zou; Zejun Deng; Xinhong Yu; Manman Zhang; Sihan Zhao; Ting Luo; Xin Yin; Hui Xu; Wei Wang

doi:10.1007/s11426-011-4445-1

A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-l-proline with aldehydes

Zhiqin Zou
, Zejun Deng
, Xinhong Yu
, Manman Zhang
, Sihan Zhao
, Ting Luo
, Xin Yin
, Hui Xu
, Wei Wang

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

An unprecedented acetic acid-catalyzed efficient access to N-alkylpyrroles from reaction of 4-hydroxy-l-proline with a variety of aldehydes has been achieved in good to excellent yields under mild reaction conditions.

Original language	English (US)
Pages (from-to)	43-49
Number of pages	7
Journal	Science China Chemistry
Volume	55
Issue number	1
DOIs	https://doi.org/10.1007/s11426-011-4445-1
State	Published - Jan 2012
Externally published	Yes

Keywords

aromatization
decarboxylation
enamines
iminium
redox isomerization

ASJC Scopus subject areas

General Chemistry

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10.1007/s11426-011-4445-1

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title = "A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-l-proline with aldehydes",

abstract = "An unprecedented acetic acid-catalyzed efficient access to N-alkylpyrroles from reaction of 4-hydroxy-l-proline with a variety of aldehydes has been achieved in good to excellent yields under mild reaction conditions.",

keywords = "aromatization, decarboxylation, enamines, iminium, redox isomerization",

author = "Zhiqin Zou and Zejun Deng and Xinhong Yu and Manman Zhang and Sihan Zhao and Ting Luo and Xin Yin and Hui Xu and Wei Wang",

note = "Funding Information: We gratefully acknowledge financial support from the National Natural Science Foundation of China (20972051), the Science and Technology Commission of Shanghai Municipality (08430703900 \& 08431901800), the 111 Project (B07023), and East China University of Science \& Technology.",

year = "2012",

month = jan,

doi = "10.1007/s11426-011-4445-1",

language = "English (US)",

volume = "55",

pages = "43--49",

journal = "Science China Chemistry",

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T1 - A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-l-proline with aldehydes

AU - Zou, Zhiqin

AU - Deng, Zejun

AU - Yu, Xinhong

AU - Zhang, Manman

AU - Zhao, Sihan

AU - Luo, Ting

AU - Yin, Xin

AU - Xu, Hui

AU - Wang, Wei

N1 - Funding Information: We gratefully acknowledge financial support from the National Natural Science Foundation of China (20972051), the Science and Technology Commission of Shanghai Municipality (08430703900 & 08431901800), the 111 Project (B07023), and East China University of Science & Technology.

PY - 2012/1

Y1 - 2012/1

N2 - An unprecedented acetic acid-catalyzed efficient access to N-alkylpyrroles from reaction of 4-hydroxy-l-proline with a variety of aldehydes has been achieved in good to excellent yields under mild reaction conditions.

AB - An unprecedented acetic acid-catalyzed efficient access to N-alkylpyrroles from reaction of 4-hydroxy-l-proline with a variety of aldehydes has been achieved in good to excellent yields under mild reaction conditions.

KW - aromatization

KW - decarboxylation

KW - enamines

KW - iminium

KW - redox isomerization

UR - https://www.scopus.com/pages/publications/84856318401

UR - https://www.scopus.com/pages/publications/84856318401#tab=citedBy

U2 - 10.1007/s11426-011-4445-1

DO - 10.1007/s11426-011-4445-1

M3 - Article

AN - SCOPUS:84856318401

SN - 1674-7291

VL - 55

SP - 43

EP - 49

JO - Science China Chemistry

JF - Science China Chemistry

IS - 1

ER -

A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-l-proline with aldehydes

Abstract

Keywords

ASJC Scopus subject areas

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