A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-l-proline with aldehydes

Zhiqin Zou, Zejun Deng, Xinhong Yu, Manman Zhang, Sihan Zhao, Ting Luo, Xin Yin, Hui Xu, Wei Wang

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

An unprecedented acetic acid-catalyzed efficient access to N-alkylpyrroles from reaction of 4-hydroxy-l-proline with a variety of aldehydes has been achieved in good to excellent yields under mild reaction conditions.

Original languageEnglish (US)
Pages (from-to)43-49
Number of pages7
JournalScience China Chemistry
Volume55
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Keywords

  • aromatization
  • decarboxylation
  • enamines
  • iminium
  • redox isomerization

ASJC Scopus subject areas

  • Chemistry(all)

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