TY - JOUR
T1 - A New Case of γ‐Heavy Chain Disease
T2 - Clinical and Immunochemical Studies
AU - Cozzolino, Federico
AU - Vercelli, Donata
AU - Castigli, Emanuela
AU - Becucci, Aureliano
AU - Guglielmo, Renato Di
PY - 1982/2
Y1 - 1982/2
N2 - The detection of a γ‐heavy chain disease protein in the serum and urine of a patient with a history of Hodgkin's disease in complete remission is reported. The protein has been characterized as a γ1 dimer, MW 66000, beginning at Asp 221 residue in the hinge region. No clinical or laboratory findings of malignancy have been observed in the patient since the abnormal protein was detected. The pathogenesis of this association, unreported to date, is discussed on the basis of previously administered high‐dose anti‐neoplastic treatments and of immunological impairment.
AB - The detection of a γ‐heavy chain disease protein in the serum and urine of a patient with a history of Hodgkin's disease in complete remission is reported. The protein has been characterized as a γ1 dimer, MW 66000, beginning at Asp 221 residue in the hinge region. No clinical or laboratory findings of malignancy have been observed in the patient since the abnormal protein was detected. The pathogenesis of this association, unreported to date, is discussed on the basis of previously administered high‐dose anti‐neoplastic treatments and of immunological impairment.
KW - Hodgkin's disease
KW - γ‐heavy chain disease
UR - http://www.scopus.com/inward/record.url?scp=0020044031&partnerID=8YFLogxK
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U2 - 10.1111/j.1600-0609.1982.tb00507.x
DO - 10.1111/j.1600-0609.1982.tb00507.x
M3 - Article
C2 - 6806895
AN - SCOPUS:0020044031
SN - 0036-553X
VL - 28
SP - 145
EP - 150
JO - Scandinavian Journal of Haematology
JF - Scandinavian Journal of Haematology
IS - 2
ER -