A New Case of γ‐Heavy Chain Disease: Clinical and Immunochemical Studies

Federico Cozzolino, Donata Vercelli, Emanuela Castigli, Aureliano Becucci, Renato Di Guglielmo

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The detection of a γ‐heavy chain disease protein in the serum and urine of a patient with a history of Hodgkin's disease in complete remission is reported. The protein has been characterized as a γ1 dimer, MW 66000, beginning at Asp 221 residue in the hinge region. No clinical or laboratory findings of malignancy have been observed in the patient since the abnormal protein was detected. The pathogenesis of this association, unreported to date, is discussed on the basis of previously administered high‐dose anti‐neoplastic treatments and of immunological impairment.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalScandinavian Journal of Haematology
Issue number2
StatePublished - Feb 1982


  • Hodgkin's disease
  • γ‐heavy chain disease

ASJC Scopus subject areas

  • Hematology


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