A naphthalimide-aminal-based pH-sensitive fluorescent donor for lysosome-targeted formaldehyde release and fluorescence turn-on readout

Huan Xu, Hang Xu, Shengnan Ma, Qianqian Liu, Lixian Huang, Peimin Wu, Xiaolin Liu, Yali Huang, Xiaolei Wang, Kaiyan Lou, Wei Wang

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

A naphthalimide-aminal-based fluorescent donor (NAP-FAD-1) is a pH-sensitive smart donor, which features accelerated FA release at pH 5.0 compared to that at pH 7.4 and fluorescence turn-on readout for facile tracking and quantification of FA release. Confocal imaging studies of HeLa cells co-incubated with Lyso-Tracker Red suggested that its FA release is lysosome-targeted.

Original languageEnglish (US)
Pages (from-to)7053-7056
Number of pages4
JournalChemical Communications
Volume55
Issue number49
DOIs
StatePublished - 2019

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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