A naphthalimide-aminal-based pH-sensitive fluorescent donor for lysosome-targeted formaldehyde release and fluorescence turn-on readout

Huan Xu; Hang Xu; Shengnan Ma; Qianqian Liu; Lixian Huang; Peimin Wu; Xiaolin Liu; Yali Huang; Xiaolei Wang; Kaiyan Lou; Wei Wang

doi:10.1039/c9cc02481f

A naphthalimide-aminal-based pH-sensitive fluorescent donor for lysosome-targeted formaldehyde release and fluorescence turn-on readout

Huan Xu, Hang Xu, Shengnan Ma, Qianqian Liu, Lixian Huang, Peimin Wu, Xiaolin Liu, Yali Huang, Xiaolei Wang, Kaiyan Lou, Wei Wang

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A naphthalimide-aminal-based fluorescent donor (NAP-FAD-1) is a pH-sensitive smart donor, which features accelerated FA release at pH 5.0 compared to that at pH 7.4 and fluorescence turn-on readout for facile tracking and quantification of FA release. Confocal imaging studies of HeLa cells co-incubated with Lyso-Tracker Red suggested that its FA release is lysosome-targeted.

Original language	English (US)
Pages (from-to)	7053-7056
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	49
DOIs	https://doi.org/10.1039/c9cc02481f
State	Published - 2019

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "A naphthalimide-aminal-based pH-sensitive fluorescent donor for lysosome-targeted formaldehyde release and fluorescence turn-on readout",

abstract = "A naphthalimide-aminal-based fluorescent donor (NAP-FAD-1) is a pH-sensitive smart donor, which features accelerated FA release at pH 5.0 compared to that at pH 7.4 and fluorescence turn-on readout for facile tracking and quantification of FA release. Confocal imaging studies of HeLa cells co-incubated with Lyso-Tracker Red suggested that its FA release is lysosome-targeted.",

author = "Huan Xu and Hang Xu and Shengnan Ma and Qianqian Liu and Lixian Huang and Peimin Wu and Xiaolin Liu and Yali Huang and Xiaolei Wang and Kaiyan Lou and Wei Wang",

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AU - Xu, Huan

AU - Xu, Hang

AU - Ma, Shengnan

AU - Liu, Qianqian

AU - Huang, Lixian

AU - Wu, Peimin

AU - Liu, Xiaolin

AU - Huang, Yali

AU - Wang, Xiaolei

AU - Lou, Kaiyan

AU - Wang, Wei

PY - 2019

Y1 - 2019

N2 - A naphthalimide-aminal-based fluorescent donor (NAP-FAD-1) is a pH-sensitive smart donor, which features accelerated FA release at pH 5.0 compared to that at pH 7.4 and fluorescence turn-on readout for facile tracking and quantification of FA release. Confocal imaging studies of HeLa cells co-incubated with Lyso-Tracker Red suggested that its FA release is lysosome-targeted.

AB - A naphthalimide-aminal-based fluorescent donor (NAP-FAD-1) is a pH-sensitive smart donor, which features accelerated FA release at pH 5.0 compared to that at pH 7.4 and fluorescence turn-on readout for facile tracking and quantification of FA release. Confocal imaging studies of HeLa cells co-incubated with Lyso-Tracker Red suggested that its FA release is lysosome-targeted.

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JO - Chemical Communications

JF - Chemical Communications

IS - 49

ER -

A naphthalimide-aminal-based pH-sensitive fluorescent donor for lysosome-targeted formaldehyde release and fluorescence turn-on readout

Abstract

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