Abstract
Into low force regime: A universal molecular force probe for measuring by AFM the strength of receptor-ligand and protein-protein complexes was developed. The protein-based force probe has the sensitivity on the order of piconewtons and provides a single-molecule fingerprint for identifying mechanical rupture events of individual complexes (see picture).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1903-1906 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Issue number | 8 |
| DOIs | |
| State | Published - Feb 20 2012 |
| Externally published | Yes |
Keywords
- bond rupture measurements
- ligand-receptor interactions
- protein engineering
- protein-protein interactions
- single-molecule force spectroscopy
ASJC Scopus subject areas
- Catalysis
- General Chemistry
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