A nanoscale force probe for gauging intermolecular interactions

Minkyu Kim; Chien Chung Wang; Fabrizio Benedetti; Piotr E. Marszalek

doi:10.1002/anie.201107210

A nanoscale force probe for gauging intermolecular interactions

Minkyu Kim, Chien Chung Wang, Fabrizio Benedetti, Piotr E. Marszalek

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Into low force regime: A universal molecular force probe for measuring by AFM the strength of receptor-ligand and protein-protein complexes was developed. The protein-based force probe has the sensitivity on the order of piconewtons and provides a single-molecule fingerprint for identifying mechanical rupture events of individual complexes (see picture).

Original language	English (US)
Pages (from-to)	1903-1906
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	8
DOIs	https://doi.org/10.1002/anie.201107210
State	Published - Feb 20 2012
Externally published	Yes

Keywords

bond rupture measurements
ligand-receptor interactions
protein engineering
protein-protein interactions
single-molecule force spectroscopy

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201107210

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title = "A nanoscale force probe for gauging intermolecular interactions",

abstract = "Into low force regime: A universal molecular force probe for measuring by AFM the strength of receptor-ligand and protein-protein complexes was developed. The protein-based force probe has the sensitivity on the order of piconewtons and provides a single-molecule fingerprint for identifying mechanical rupture events of individual complexes (see picture).",

keywords = "bond rupture measurements, ligand-receptor interactions, protein engineering, protein-protein interactions, single-molecule force spectroscopy",

author = "Minkyu Kim and Wang, {Chien Chung} and Fabrizio Benedetti and Marszalek, {Piotr E.}",

year = "2012",

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AU - Kim, Minkyu

AU - Wang, Chien Chung

AU - Benedetti, Fabrizio

AU - Marszalek, Piotr E.

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N2 - Into low force regime: A universal molecular force probe for measuring by AFM the strength of receptor-ligand and protein-protein complexes was developed. The protein-based force probe has the sensitivity on the order of piconewtons and provides a single-molecule fingerprint for identifying mechanical rupture events of individual complexes (see picture).

AB - Into low force regime: A universal molecular force probe for measuring by AFM the strength of receptor-ligand and protein-protein complexes was developed. The protein-based force probe has the sensitivity on the order of piconewtons and provides a single-molecule fingerprint for identifying mechanical rupture events of individual complexes (see picture).

KW - bond rupture measurements

KW - ligand-receptor interactions

KW - protein engineering

KW - protein-protein interactions

KW - single-molecule force spectroscopy

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A nanoscale force probe for gauging intermolecular interactions

Abstract

Keywords

ASJC Scopus subject areas

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