A nanoscale force probe for gauging intermolecular interactions

Minkyu Kim, Chien Chung Wang, Fabrizio Benedetti, Piotr E. Marszalek

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Into low force regime: A universal molecular force probe for measuring by AFM the strength of receptor-ligand and protein-protein complexes was developed. The protein-based force probe has the sensitivity on the order of piconewtons and provides a single-molecule fingerprint for identifying mechanical rupture events of individual complexes (see picture).

Original languageEnglish (US)
Pages (from-to)1903-1906
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number8
StatePublished - Feb 20 2012


  • bond rupture measurements
  • ligand-receptor interactions
  • protein engineering
  • protein-protein interactions
  • single-molecule force spectroscopy

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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