A mild and selective protecting and reversed modification of thiols

Xiangmin Li; Hongxian Li; Wei Yang; Jinchen Zhuang; Hao Li; Wei Wang

doi:10.1016/j.tetlet.2016.05.027

A mild and selective protecting and reversed modification of thiols

Xiangmin Li
, Hongxian Li
, Wei Yang
, Jinchen Zhuang
, Hao Li
, Wei Wang

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

One selective thiol-protecting study has been investigated for a wide range of thiols including general thiols and thiols containing multiple functional groups. The reactions of bromomaleimides and thiols under the mild condition afforded the protected products in excellent yields. The thiols can be recovered very quickly using dithiothreitol (DTT) under the mild condition.

Original language	English (US)
Pages (from-to)	2660-2663
Number of pages	4
Journal	Tetrahedron Letters
Volume	57
Issue number	24
DOIs	https://doi.org/10.1016/j.tetlet.2016.05.027
State	Published - Jun 15 2016
Externally published	Yes

Keywords

Bromomaleimide
Deprotecting
Protecting
Selective
Thiols

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2016.05.027

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title = "A mild and selective protecting and reversed modification of thiols",

abstract = "One selective thiol-protecting study has been investigated for a wide range of thiols including general thiols and thiols containing multiple functional groups. The reactions of bromomaleimides and thiols under the mild condition afforded the protected products in excellent yields. The thiols can be recovered very quickly using dithiothreitol (DTT) under the mild condition.",

keywords = "Bromomaleimide, Deprotecting, Protecting, Selective, Thiols",

author = "Xiangmin Li and Hongxian Li and Wei Yang and Jinchen Zhuang and Hao Li and Wei Wang",

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T1 - A mild and selective protecting and reversed modification of thiols

AU - Li, Xiangmin

AU - Li, Hongxian

AU - Yang, Wei

AU - Zhuang, Jinchen

AU - Li, Hao

AU - Wang, Wei

PY - 2016/6/15

Y1 - 2016/6/15

N2 - One selective thiol-protecting study has been investigated for a wide range of thiols including general thiols and thiols containing multiple functional groups. The reactions of bromomaleimides and thiols under the mild condition afforded the protected products in excellent yields. The thiols can be recovered very quickly using dithiothreitol (DTT) under the mild condition.

AB - One selective thiol-protecting study has been investigated for a wide range of thiols including general thiols and thiols containing multiple functional groups. The reactions of bromomaleimides and thiols under the mild condition afforded the protected products in excellent yields. The thiols can be recovered very quickly using dithiothreitol (DTT) under the mild condition.

KW - Bromomaleimide

KW - Deprotecting

KW - Protecting

KW - Selective

KW - Thiols

UR - https://www.scopus.com/pages/publications/84969505850

UR - https://www.scopus.com/pages/publications/84969505850#tab=citedBy

U2 - 10.1016/j.tetlet.2016.05.027

DO - 10.1016/j.tetlet.2016.05.027

M3 - Article

AN - SCOPUS:84969505850

SN - 0040-4039

VL - 57

SP - 2660

EP - 2663

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 24

ER -

A mild and selective protecting and reversed modification of thiols

Abstract

Keywords

ASJC Scopus subject areas

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