A mild and selective protecting and reversed modification of thiols

Xiangmin Li, Hongxian Li, Wei Yang, Jinchen Zhuang, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


One selective thiol-protecting study has been investigated for a wide range of thiols including general thiols and thiols containing multiple functional groups. The reactions of bromomaleimides and thiols under the mild condition afforded the protected products in excellent yields. The thiols can be recovered very quickly using dithiothreitol (DTT) under the mild condition.

Original languageEnglish (US)
Pages (from-to)2660-2663
Number of pages4
JournalTetrahedron Letters
Issue number24
StatePublished - Jun 15 2016
Externally publishedYes


  • Bromomaleimide
  • Deprotecting
  • Protecting
  • Selective
  • Thiols

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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