A method for the rapid estimation of sublimation rates of organic compounds at standard temperature and pressure

Marc Tesconi; Michael J. Pikal; Samuel H. Yalkowsky

doi:10.1021/js9700356

A method for the rapid estimation of sublimation rates of organic compounds at standard temperature and pressure

Marc Tesconi, Michael J. Pikal, Samuel H. Yalkowsky

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A method for the rapid estimation of the sublimation rates of organic compounds at standard temperature and pressure (STP; 298 K and 101.3 kPa, respectively) is presented. Thermogravimetric analysis was used to obtain accelerated sublimation rates for anthracene at a series of elevated temperatures and reduced pressures. An empirical equation relating these parameters was used to extrapolate to the STP sublimation rate. This value is in good agreement with the measured value.

Original language	English (US)
Pages (from-to)	1299-1302
Number of pages	4
Journal	Journal of pharmaceutical sciences
Volume	86
Issue number	11
DOIs	https://doi.org/10.1021/js9700356
State	Published - Nov 1997

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Pharmaceutical Science

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10.1021/js9700356

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title = "A method for the rapid estimation of sublimation rates of organic compounds at standard temperature and pressure",

abstract = "A method for the rapid estimation of the sublimation rates of organic compounds at standard temperature and pressure (STP; 298 K and 101.3 kPa, respectively) is presented. Thermogravimetric analysis was used to obtain accelerated sublimation rates for anthracene at a series of elevated temperatures and reduced pressures. An empirical equation relating these parameters was used to extrapolate to the STP sublimation rate. This value is in good agreement with the measured value.",

author = "Marc Tesconi and Pikal, {Michael J.} and Yalkowsky, {Samuel H.}",

note = "Funding Information: This work was supported by a fellowship from the Pharmaceutical Research and Manufacturers of America Foundation, Inc.",

year = "1997",

month = nov,

doi = "10.1021/js9700356",

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T1 - A method for the rapid estimation of sublimation rates of organic compounds at standard temperature and pressure

AU - Tesconi, Marc

AU - Pikal, Michael J.

AU - Yalkowsky, Samuel H.

N1 - Funding Information: This work was supported by a fellowship from the Pharmaceutical Research and Manufacturers of America Foundation, Inc.

PY - 1997/11

Y1 - 1997/11

N2 - A method for the rapid estimation of the sublimation rates of organic compounds at standard temperature and pressure (STP; 298 K and 101.3 kPa, respectively) is presented. Thermogravimetric analysis was used to obtain accelerated sublimation rates for anthracene at a series of elevated temperatures and reduced pressures. An empirical equation relating these parameters was used to extrapolate to the STP sublimation rate. This value is in good agreement with the measured value.

AB - A method for the rapid estimation of the sublimation rates of organic compounds at standard temperature and pressure (STP; 298 K and 101.3 kPa, respectively) is presented. Thermogravimetric analysis was used to obtain accelerated sublimation rates for anthracene at a series of elevated temperatures and reduced pressures. An empirical equation relating these parameters was used to extrapolate to the STP sublimation rate. This value is in good agreement with the measured value.

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A method for the rapid estimation of sublimation rates of organic compounds at standard temperature and pressure

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