A Metal-free Approach to 3-Aryl-3-hydroxy-2-oxindoles by Treatment of 3-Acyloxy-2-oxindoles with Diaryliodonium Salts

Xiaokang Li, Wei Ni, Fei Mao, Wei Wang, Jian Li

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A mild, metal-free approach has been realized for the facile construction of highly valuable 3-(hetero)aryl-3-hydroxy-2-oxindoles. Direct arylations of 3-acyloxy-2-oxindoles with diaryliodonium salts as arylation reagents are implemented in the presence of K2CO3 at room temperature without using an organometallic promoter to deliver an array of 3-(hetero)aryl-3-hydroxy-2-oxindoles in good yields. A new family member: A simple and efficient method for direct arylation of 3-acyloxy-2-oxindoles has been developed. Direct arylations of 3-acyloxy-2-oxindoles with diaryliodonium salts as arylation reagents are implemented in the presence of K2CO3 at room temperature without using an organometallic promoter to deliver an array of 3-(hetero)aryl-3-hydroxy-2-oxindoles in good yields.

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalChemistry - An Asian Journal
Volume11
Issue number2
DOIs
StatePublished - Jan 20 2016
Externally publishedYes

Keywords

  • 3-acyloxy-2-oxindoles
  • 3-aryl-3-hydroxy-2-oxindole
  • arylation
  • diaryliodonium salt
  • metal-free

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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