A limited number of genes are involved in the differentiation of germinal center B cells

Yasuhiro Nakayama, Paul Stabach, Stephen E. Maher, Milind C. Mahajan, Peter Masiar, Cheng Liao, Xueqing Zhang, Zhi Jia Ye, David Tuck, Alfred L.M. Bothwell, Peter E. Newburger, Sherman M. Weissman

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Mature B cells, upon activation, progressively differentiate through centroblasts into centrocytes and finally to plasmacytes that express large amounts of selected immunoglobulins. A significant part of this maturation is thought to involve induction of the unfolded protein response (UPR). We have compared gene expression in normal germinal center centroblasts, centrocytes, lymphoblastoid cells undergoing induced UPR, and the CCL155 plasmacytoma cell line. In the centroblast to centrocyte transition there is a change in the expression of a relatively small number of genes. These include a limited subset of the genes upregulated by a fully activated UPR as well as a small number of other transcription factors, some disulfide isomerases, and other genes. This is consistent with a model in which this transition is mediated by changes in the levels of expression of transcription factor B-lymphocyte-induced maturation protein 1 (Blimp1) (PRDM1), BACH2, X-box binding protein 1 (XBP1), interferon regulatory factor 4 (IRF4), and possibly vitamin D receptor (VDR) expression, together with post-transcriptional changes and a limited induction of aspects of the UPR.

Original languageEnglish (US)
Pages (from-to)1308-1325
Number of pages18
JournalJournal of Cellular Biochemistry
Issue number5
StatePublished - Dec 1 2006
Externally publishedYes


  • Centroblast
  • Centrocyte
  • Gene expression
  • Germinal center
  • Transcription factor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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