A hybrid model of a genetic regulatory network in mammalian sclera

Qin Shu; Diana Catalina Ardila; Ricardo G. Sanfelice; Jonathan P. Vande Geest

doi:10.4204/EPTCS.125.8

A hybrid model of a genetic regulatory network in mammalian sclera

Qin Shu
, Diana Catalina Ardila
, Ricardo G. Sanfelice
, Jonathan P. Vande Geest

Aerospace & Mechanical Engr

Research output: Contribution to journal › Conference article › peer-review

Abstract

Myopia in human and animals is caused by the axial elongation of the eye and is closely linked to the thinning of the sclera which supports the eye tissue. This thinning has been correlated with the overproduction of matrix metalloproteinase (MMP-2), an enzyme that degrades the collagen structure of the sclera. In this short paper, we propose a descriptive model of a regulatory network with hysteresis, which seems necessary for creating oscillatory behavior in the hybrid model between MMP-2, MT1-MMP and TIMP-2. Numerical results provide insight on the type of equilibria present in the system.

Original language	English (US)
Pages (from-to)	99-105
Number of pages	7
Journal	Electronic Proceedings in Theoretical Computer Science, EPTCS
Volume	125
DOIs	https://doi.org/10.4204/EPTCS.125.8
State	Published - Aug 27 2013
Event	2nd International Workshop on Hybrid Systems and Biology, HSB 2013 - Taormina, Italy Duration: Sep 2 2013 → …

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title = "A hybrid model of a genetic regulatory network in mammalian sclera",

abstract = "Myopia in human and animals is caused by the axial elongation of the eye and is closely linked to the thinning of the sclera which supports the eye tissue. This thinning has been correlated with the overproduction of matrix metalloproteinase (MMP-2), an enzyme that degrades the collagen structure of the sclera. In this short paper, we propose a descriptive model of a regulatory network with hysteresis, which seems necessary for creating oscillatory behavior in the hybrid model between MMP-2, MT1-MMP and TIMP-2. Numerical results provide insight on the type of equilibria present in the system.",

author = "Qin Shu and Ardila, \{Diana Catalina\} and Sanfelice, \{Ricardo G.\} and \{Vande Geest\}, \{Jonathan P.\}",

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AU - Shu, Qin

AU - Ardila, Diana Catalina

AU - Sanfelice, Ricardo G.

AU - Vande Geest, Jonathan P.

N1 - Publisher Copyright: © Q. Shu, D. C. Ardila, R. G. Sanfelice, and J. P. Vande Geest.

PY - 2013/8/27

Y1 - 2013/8/27

N2 - Myopia in human and animals is caused by the axial elongation of the eye and is closely linked to the thinning of the sclera which supports the eye tissue. This thinning has been correlated with the overproduction of matrix metalloproteinase (MMP-2), an enzyme that degrades the collagen structure of the sclera. In this short paper, we propose a descriptive model of a regulatory network with hysteresis, which seems necessary for creating oscillatory behavior in the hybrid model between MMP-2, MT1-MMP and TIMP-2. Numerical results provide insight on the type of equilibria present in the system.

AB - Myopia in human and animals is caused by the axial elongation of the eye and is closely linked to the thinning of the sclera which supports the eye tissue. This thinning has been correlated with the overproduction of matrix metalloproteinase (MMP-2), an enzyme that degrades the collagen structure of the sclera. In this short paper, we propose a descriptive model of a regulatory network with hysteresis, which seems necessary for creating oscillatory behavior in the hybrid model between MMP-2, MT1-MMP and TIMP-2. Numerical results provide insight on the type of equilibria present in the system.

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A hybrid model of a genetic regulatory network in mammalian sclera

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