A hybrid model of a genetic regulatory network in mammalian sclera

Qin Shu, Diana Catalina Ardila, Ricardo G. Sanfelice, Jonathan P. Vande Geest

Research output: Contribution to journalConference articlepeer-review


Myopia in human and animals is caused by the axial elongation of the eye and is closely linked to the thinning of the sclera which supports the eye tissue. This thinning has been correlated with the overproduction of matrix metalloproteinase (MMP-2), an enzyme that degrades the collagen structure of the sclera. In this short paper, we propose a descriptive model of a regulatory network with hysteresis, which seems necessary for creating oscillatory behavior in the hybrid model between MMP-2, MT1-MMP and TIMP-2. Numerical results provide insight on the type of equilibria present in the system.

Original languageEnglish (US)
Pages (from-to)99-105
Number of pages7
JournalElectronic Proceedings in Theoretical Computer Science, EPTCS
StatePublished - Aug 27 2013
Event2nd International Workshop on Hybrid Systems and Biology, HSB 2013 - Taormina, Italy
Duration: Sep 2 2013 → …

ASJC Scopus subject areas

  • Software


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