A histological variant of white spot syndrome virus (WSSV) from the Kingdom of Saudi Arabia

Kathy F.J. Tang, Carlos R. Pantoja, Rita M. Redman, Donald V. Lightner

    Research output: Contribution to journalArticlepeer-review

    9 Scopus citations


    White spot syndrome virus (WSSV) is highly pathogenic to penaeid shrimp. The major targets of WSSV infection are tissues of ectodermal and mesodermal embryonic origin, predominantly the cuticular epithelium and subcuticular connective tissues. Recently, we discovered a WSSV variant in Penaeus indicus that heavily infects the subcuticular connective tissue, with very slight indications in the cuticular epithelium. The variant was also unusual in that WSSV accumulations were found in the interstitial spaces of both the subcuticular connective tissue and the lymphoid organ. This WSSV variant was confirmed through immunohistochemistry with an anti-WSSV VP28 monoclonal antibody, and also by in situ hybridization with a VP28 DNA probe. By in situ hybridization, shrimp with variant and typical histology were shown a deletion in ORF94, which is characteristic of a new type of WSSV found in Saudi Arabia; apparently, the loss of this ORF is not associated with the variant's reduced capability of infecting the cuticular epithelium cells.

    Original languageEnglish (US)
    Pages (from-to)82-85
    Number of pages4
    JournalJournal of Invertebrate Pathology
    Issue number1
    StatePublished - May 1 2013


    • Histology variant
    • Immunohistochemistry
    • In situ hybridization
    • Penaeid shrimp
    • WSSV
    • White spot syndrome virus

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics


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