A heterozygous moth genome provides insights into herbivory and detoxification

Minsheng You; Zhen Yue; Weiyi He; Xinhua Yang; Guang Yang; Miao Xie; Dongliang Zhan; Simon W. Baxter; Liette Vasseur; Geoff M. Gurr; Carl J. Douglas; Jianlin Bai; Ping Wang; Kai Cui; Shiguo Huang; Xianchun Li; Qing Zhou; Zhangyan Wu; Qilin Chen; Chunhui Liu; Bo Wang; Xiaojing Li; Xiufeng Xu; Changxin Lu; Min Hu; John W. Davey; Sandy M. Smith; Mingshun Chen; Xiaofeng Xia; Weiqi Tang; Fushi Ke; Dandan Zheng; Yulan Hu; Fengqin Song; Yanchun You; Xiaoli Ma; Lu Peng; Yunkai Zheng; Yong Liang; Yaqiong Chen; Liying Yu; Younan Zhang; Yuanyuan Liu; Guoqing Li; Lin Fang; Jingxiang Li; Xin Zhou; Yadan Luo; Caiyun Gou; Junyi Wang; Jian Wang; Huanming Yang; Jan Wang

doi:10.1038/ng.2524

A heterozygous moth genome provides insights into herbivory and detoxification

Minsheng You, Zhen Yue, Weiyi He, Xinhua Yang, Guang Yang, Miao Xie, Dongliang Zhan, Simon W. Baxter, Liette Vasseur, Geoff M. Gurr, Carl J. Douglas, Jianlin Bai, Ping Wang, Kai Cui, Shiguo Huang, Xianchun Li, Qing Zhou, Zhangyan Wu, Qilin Chen, Chunhui LiuBo Wang, Xiaojing Li, Xiufeng Xu, Changxin Lu, Min Hu, John W. Davey, Sandy M. Smith, Mingshun Chen, Xiaofeng Xia, Weiqi Tang, Fushi Ke, Dandan Zheng, Yulan Hu, Fengqin Song, Yanchun You, Xiaoli Ma, Lu Peng, Yunkai Zheng, Yong Liang, Yaqiong Chen, Liying Yu, Younan Zhang, Yuanyuan Liu, Guoqing Li, Lin Fang, Jingxiang Li, Xin Zhou, Yadan Luo, Caiyun Gou, Junyi Wang, Jian Wang, Huanming Yang, Jan Wang

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Abstract

How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically related host plants, but the genetic and molecular bases for adaptation to plant defense compounds remain poorly understood. We report the first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated with perception and the detoxification of plant defense compounds. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to also be involved in the development of insecticide resistance. This work shows the genetic and molecular bases for the evolutionary success of this worldwide herbivore and offers wider insights into insect adaptation to plant feeding, as well as opening avenues for more sustainable pest management.

Original language	English (US)
Pages (from-to)	220-225
Number of pages	6
Journal	Nature Genetics
Volume	45
Issue number	2
DOIs	https://doi.org/10.1038/ng.2524
State	Published - Feb 2013

ASJC Scopus subject areas

Genetics

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10.1038/ng.2524

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You, M, Yue, Z, He, W, Yang, X, Yang, G, Xie, M, Zhan, D, Baxter, SW, Vasseur, L, Gurr, GM, Douglas, CJ, Bai, J, Wang, P, Cui, K, Huang, S, Li, X, Zhou, Q, Wu, Z, Chen, Q, Liu, C, Wang, B, Li, X, Xu, X, Lu, C, Hu, M, Davey, JW, Smith, SM, Chen, M, Xia, X, Tang, W, Ke, F, Zheng, D, Hu, Y, Song, F, You, Y, Ma, X, Peng, L, Zheng, Y, Liang, Y, Chen, Y, Yu, L, Zhang, Y, Liu, Y, Li, G, Fang, L, Li, J, Zhou, X, Luo, Y, Gou, C, Wang, J, Wang, J, Yang, H & Wang, J 2013, 'A heterozygous moth genome provides insights into herbivory and detoxification', Nature Genetics, vol. 45, no. 2, pp. 220-225. https://doi.org/10.1038/ng.2524

@article{55b76a0e28b04481918e92cc17ce9e1d,

title = "A heterozygous moth genome provides insights into herbivory and detoxification",

abstract = "How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically related host plants, but the genetic and molecular bases for adaptation to plant defense compounds remain poorly understood. We report the first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated with perception and the detoxification of plant defense compounds. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to also be involved in the development of insecticide resistance. This work shows the genetic and molecular bases for the evolutionary success of this worldwide herbivore and offers wider insights into insect adaptation to plant feeding, as well as opening avenues for more sustainable pest management.",

author = "Minsheng You and Zhen Yue and Weiyi He and Xinhua Yang and Guang Yang and Miao Xie and Dongliang Zhan and Baxter, {Simon W.} and Liette Vasseur and Gurr, {Geoff M.} and Douglas, {Carl J.} and Jianlin Bai and Ping Wang and Kai Cui and Shiguo Huang and Xianchun Li and Qing Zhou and Zhangyan Wu and Qilin Chen and Chunhui Liu and Bo Wang and Xiaojing Li and Xiufeng Xu and Changxin Lu and Min Hu and Davey, {John W.} and Smith, {Sandy M.} and Mingshun Chen and Xiaofeng Xia and Weiqi Tang and Fushi Ke and Dandan Zheng and Yulan Hu and Fengqin Song and Yanchun You and Xiaoli Ma and Lu Peng and Yunkai Zheng and Yong Liang and Yaqiong Chen and Liying Yu and Younan Zhang and Yuanyuan Liu and Guoqing Li and Lin Fang and Jingxiang Li and Xin Zhou and Yadan Luo and Caiyun Gou and Junyi Wang and Jian Wang and Huanming Yang and Jan Wang",

note = "Funding Information: This work was supported through a special project of Research on Diamondback Moth Genomics (grant JB09315) to M.Y. and a Minjiang Scholar Program to L.V., G.M.G., C.J.D. and S.M.S. by the Educational Department of Fujian Province and through a key project (grant 31230061) to M.Y. from the National Natural Science Foundation of China. Insect rearing and sampling, as well as some of the DNA extractions, were conducted at the Fujian Provincial Key Laboratory of Biodiversity and Eco-safety and the Key Laboratory of Integrated Pest Management for Fujian-Taiwan Crops, the Ministry of Agriculture, China. We are grateful to A.D. Briscoe (University of California–Irvine) for her help in organizing and for providing ORs, OBPs and CSPs from Danaus plexippus and Heliconius melpomene and to G.L. L{\"o}vei (Aarhus University) for his comments and suggestions on the manuscript. We appreciate J. Liao and M. Zou (Fujian Agriculture and Forestry University) for providing the Bt-treated P. xylostella larvae used for quantitative gene expression analysis. We thank H. Wang, J. Luo, Y. Hong, S. Pan, L. Yang, Y. Weng, Y. Hong and Y. Liu for their technical assistance in rearing insects and preparing samples.",

year = "2013",

month = feb,

doi = "10.1038/ng.2524",

language = "English (US)",

volume = "45",

pages = "220--225",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "2",

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TY - JOUR

T1 - A heterozygous moth genome provides insights into herbivory and detoxification

AU - You, Minsheng

AU - Yue, Zhen

AU - He, Weiyi

AU - Yang, Xinhua

AU - Yang, Guang

AU - Xie, Miao

AU - Zhan, Dongliang

AU - Baxter, Simon W.

AU - Vasseur, Liette

AU - Gurr, Geoff M.

AU - Douglas, Carl J.

AU - Bai, Jianlin

AU - Wang, Ping

AU - Cui, Kai

AU - Huang, Shiguo

AU - Li, Xianchun

AU - Zhou, Qing

AU - Wu, Zhangyan

AU - Chen, Qilin

AU - Liu, Chunhui

AU - Wang, Bo

AU - Li, Xiaojing

AU - Xu, Xiufeng

AU - Lu, Changxin

AU - Hu, Min

AU - Davey, John W.

AU - Smith, Sandy M.

AU - Chen, Mingshun

AU - Xia, Xiaofeng

AU - Tang, Weiqi

AU - Ke, Fushi

AU - Zheng, Dandan

AU - Hu, Yulan

AU - Song, Fengqin

AU - You, Yanchun

AU - Ma, Xiaoli

AU - Peng, Lu

AU - Zheng, Yunkai

AU - Liang, Yong

AU - Chen, Yaqiong

AU - Yu, Liying

AU - Zhang, Younan

AU - Liu, Yuanyuan

AU - Li, Guoqing

AU - Fang, Lin

AU - Li, Jingxiang

AU - Zhou, Xin

AU - Luo, Yadan

AU - Gou, Caiyun

AU - Wang, Junyi

AU - Wang, Jian

AU - Yang, Huanming

AU - Wang, Jan

N1 - Funding Information: This work was supported through a special project of Research on Diamondback Moth Genomics (grant JB09315) to M.Y. and a Minjiang Scholar Program to L.V., G.M.G., C.J.D. and S.M.S. by the Educational Department of Fujian Province and through a key project (grant 31230061) to M.Y. from the National Natural Science Foundation of China. Insect rearing and sampling, as well as some of the DNA extractions, were conducted at the Fujian Provincial Key Laboratory of Biodiversity and Eco-safety and the Key Laboratory of Integrated Pest Management for Fujian-Taiwan Crops, the Ministry of Agriculture, China. We are grateful to A.D. Briscoe (University of California–Irvine) for her help in organizing and for providing ORs, OBPs and CSPs from Danaus plexippus and Heliconius melpomene and to G.L. Lövei (Aarhus University) for his comments and suggestions on the manuscript. We appreciate J. Liao and M. Zou (Fujian Agriculture and Forestry University) for providing the Bt-treated P. xylostella larvae used for quantitative gene expression analysis. We thank H. Wang, J. Luo, Y. Hong, S. Pan, L. Yang, Y. Weng, Y. Hong and Y. Liu for their technical assistance in rearing insects and preparing samples.

PY - 2013/2

Y1 - 2013/2

N2 - How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically related host plants, but the genetic and molecular bases for adaptation to plant defense compounds remain poorly understood. We report the first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated with perception and the detoxification of plant defense compounds. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to also be involved in the development of insecticide resistance. This work shows the genetic and molecular bases for the evolutionary success of this worldwide herbivore and offers wider insights into insect adaptation to plant feeding, as well as opening avenues for more sustainable pest management.

AB - How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically related host plants, but the genetic and molecular bases for adaptation to plant defense compounds remain poorly understood. We report the first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated with perception and the detoxification of plant defense compounds. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to also be involved in the development of insecticide resistance. This work shows the genetic and molecular bases for the evolutionary success of this worldwide herbivore and offers wider insights into insect adaptation to plant feeding, as well as opening avenues for more sustainable pest management.

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A heterozygous moth genome provides insights into herbivory and detoxification

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