TY - JOUR
T1 - A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in West Africans
T2 - The Africa America Diabetes Mellitus (AADM) Study
AU - Rotimi, Charles N.
AU - Chen, Guanjie
AU - Adeyemo, Adebowale A.
AU - Furbert-Harris, Paulette
AU - Guass, Debra
AU - Zhou, Jie
AU - Berg, Kate
AU - Adegoke, Olufemi
AU - Amoah, Albert
AU - Owusu, Samuel
AU - Acheampong, Joseph
AU - Agyenim-Boateng, Kofi
AU - Eghan, Benjamin A.
AU - Oli, Johnnie
AU - Okafor, Godfrey
AU - Ofoegbu, Ester
AU - Osotimehin, Babatunde
AU - Abbiyesuku, Fayeofori
AU - Johnson, Thomas
AU - Rufus, Theresa
AU - Fasanmade, Olufemi
AU - Kittles, Rick
AU - Daniel, Harold
AU - Chen, Yuanxiu
AU - Dunston, Georgia
AU - Collins, Francis S.
PY - 2004/3
Y1 - 2004/3
N2 - The incidence of type 2 diabetes is growing rapidly, not only in developed countries but also worldwide. We chose to study type 2 diabetes in West Africa, where diabetes is less common than in the U.S., reasoning that in an environment where calories are less abundant, incident cases of type 2 diabetes might carry a proportionately greater genetic component. Through the Africa America Diabetes Mellitus (AADM) study, we carried out a genome-wide linkage analysis of type 2 diabetes in a cohort of 343 affected sibling pairs (691 individuals) enrolled from five West African centers in two countries (Ghana: Accra and Kumasi; Nigeria: Enugu, Ibadan, and Lagos). A total of 390 polymorphic markers were genotyped, and multipoint linkage analysis was conducted using the GENEHUNTER-PLUS and ASM programs. Suggestive evidence of linkage was observed in four regions on three chromosomes (12, 19, and 20). The two largest logarithm of odds scores of 2.63 and 1.92 for chromosomes 20q13.3 and 12q24, respectively, are particularly interesting because these regions have been reported to harbor diabetes susceptibility genes in several other populations and ethnic groups. Given the history of forced migration of West African populations during the slave trade, these results should have considerable relevance to the study of type 2 diabetes in African Americans.
AB - The incidence of type 2 diabetes is growing rapidly, not only in developed countries but also worldwide. We chose to study type 2 diabetes in West Africa, where diabetes is less common than in the U.S., reasoning that in an environment where calories are less abundant, incident cases of type 2 diabetes might carry a proportionately greater genetic component. Through the Africa America Diabetes Mellitus (AADM) study, we carried out a genome-wide linkage analysis of type 2 diabetes in a cohort of 343 affected sibling pairs (691 individuals) enrolled from five West African centers in two countries (Ghana: Accra and Kumasi; Nigeria: Enugu, Ibadan, and Lagos). A total of 390 polymorphic markers were genotyped, and multipoint linkage analysis was conducted using the GENEHUNTER-PLUS and ASM programs. Suggestive evidence of linkage was observed in four regions on three chromosomes (12, 19, and 20). The two largest logarithm of odds scores of 2.63 and 1.92 for chromosomes 20q13.3 and 12q24, respectively, are particularly interesting because these regions have been reported to harbor diabetes susceptibility genes in several other populations and ethnic groups. Given the history of forced migration of West African populations during the slave trade, these results should have considerable relevance to the study of type 2 diabetes in African Americans.
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U2 - 10.2337/diabetes.53.3.838
DO - 10.2337/diabetes.53.3.838
M3 - Article
C2 - 14988271
AN - SCOPUS:10744222367
SN - 0012-1797
VL - 53
SP - 838
EP - 841
JO - Diabetes
JF - Diabetes
IS - 3
ER -