A Genetic study of total IgE levels in the amish

Deborah A. Meyers; W. B. Bias; D. G. Marsh

doi:10.1159/000153262

A Genetic study of total IgE levels in the amish

Deborah A. Meyers, W. B. Bias, D. G. Marsh

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Relevant to the investigation of genetic factors involved in allergic response is the mode of inheritance of IgE levels, an important factor in allergic disease. Serum total IgE levels in 208 Pennsylvania Amish individuals from 23 nuclear families were studied. Males had a significantly higher mean in IgE level than females. There was also a significant negative relationship between age and IgE levels. Segregation analysis was used to fit a major gene model to the age- and sex-adjusted data. The environmental model was rejected (χ² = 41.12, p < 0.005). The Mendelian codominant model was not rejected χ²= 8.84, p ≅ 0.03) and gave a better fit to the data than the Mendelian dominant or recessive model.

Original language	English (US)
Pages (from-to)	15-23
Number of pages	9
Journal	Human Heredity
Volume	32
Issue number	1
DOIs	https://doi.org/10.1159/000153262
State	Published - 1982
Externally published	Yes

Keywords

Allergy
Amish
IgE
Immunoglobulin

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1159/000153262

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AU - Bias, W. B.

AU - Marsh, D. G.

PY - 1982

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N2 - Relevant to the investigation of genetic factors involved in allergic response is the mode of inheritance of IgE levels, an important factor in allergic disease. Serum total IgE levels in 208 Pennsylvania Amish individuals from 23 nuclear families were studied. Males had a significantly higher mean in IgE level than females. There was also a significant negative relationship between age and IgE levels. Segregation analysis was used to fit a major gene model to the age- and sex-adjusted data. The environmental model was rejected (χ2 = 41.12, p < 0.005). The Mendelian codominant model was not rejected χ2= 8.84, p ≅ 0.03) and gave a better fit to the data than the Mendelian dominant or recessive model.

AB - Relevant to the investigation of genetic factors involved in allergic response is the mode of inheritance of IgE levels, an important factor in allergic disease. Serum total IgE levels in 208 Pennsylvania Amish individuals from 23 nuclear families were studied. Males had a significantly higher mean in IgE level than females. There was also a significant negative relationship between age and IgE levels. Segregation analysis was used to fit a major gene model to the age- and sex-adjusted data. The environmental model was rejected (χ2 = 41.12, p < 0.005). The Mendelian codominant model was not rejected χ2= 8.84, p ≅ 0.03) and gave a better fit to the data than the Mendelian dominant or recessive model.

KW - Allergy

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KW - IgE

KW - Immunoglobulin

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A Genetic study of total IgE levels in the amish

Abstract

Keywords

ASJC Scopus subject areas

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