A Genetic study of total IgE levels in the amish

Deborah A. Meyers, W. B. Bias, D. G. Marsh

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Relevant to the investigation of genetic factors involved in allergic response is the mode of inheritance of IgE levels, an important factor in allergic disease. Serum total IgE levels in 208 Pennsylvania Amish individuals from 23 nuclear families were studied. Males had a significantly higher mean in IgE level than females. There was also a significant negative relationship between age and IgE levels. Segregation analysis was used to fit a major gene model to the age- and sex-adjusted data. The environmental model was rejected (χ2 = 41.12, p < 0.005). The Mendelian codominant model was not rejected χ2= 8.84, p ≅ 0.03) and gave a better fit to the data than the Mendelian dominant or recessive model.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalHuman Heredity
Issue number1
StatePublished - 1982
Externally publishedYes


  • Allergy
  • Amish
  • IgE
  • Immunoglobulin

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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