@inproceedings{385e68f26b2742c799417e4dd8a1db99,
title = "A framework for optimizing micro-CT in dual-modality micro-CT/XFCT small-animal imaging system",
abstract = "Dual-modality Computed Tomography (CT)/X-ray Fluorescence Computed Tomography (XFCT) can be a valuable tool for imaging and quantifying the organ and tissue distribution of small concentrations of high atomic number materials in small-animal system. In this work, the framework for optimizing the micro-CT imaging system component of the dual-modality system is described, either when the micro-CT images are concurrently acquired with XFCT and using the x-ray spectral conditions for XFCT, or when the micro-CT images are acquired sequentially and independently of XFCT. This framework utilizes the cascaded systems analysis for task-specific determination of the detectability index using numerical observer models at a given radiation dose, where the radiation dose is determined using Monte Carlo simulations.",
keywords = "X-ray fluorescence computed tomography (XFCT), computed tomography (CT), small-animal imaging system",
author = "Srinivasan Vedantham and Suman Shrestha and Andrew Karellas and Cho, {Sang Hyun}",
note = "Funding Information: This work was supported in part by National Institutes of Health (NIH) grants R01 EB020658, R01 CA195512 and R01 CA199044. The contents are solely the responsibility of the authors and do not reflect the official views of the NIH. Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Radiation Detectors in Medicine, Industry, and National Security XVIII 2017 ; Conference date: 09-08-2017 Through 10-08-2017",
year = "2017",
doi = "10.1117/12.2279351",
language = "English (US)",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Grim, {Gary P.} and Furenlid, {Lars R.} and Barber, {H. Bradford}",
booktitle = "Radiation Detectors in Medicine, Industry, and National Security XVIII",
}