A framework for concepts of reserve and resilience in aging

Yaakov Stern, Marilyn Albert, Carol A. Barnes, Roberto Cabeza, Alvaro Pascual-Leone, Peter R. Rapp

Research output: Contribution to journalComment/debatepeer-review

20 Scopus citations


The study of factors, across species, that allow some individuals to age more successfully than others has important implications for individual wellbeing as well as health education, policy and intervention. Design of studies and communication across investigators in this area has been hampered by a diversity of terminology. The Collaboratory on Research Definitions for Reserve and Resilience in Cognitive Aging and Dementia was funded by the National Institute on Aging and established in 2019 as a 3-year process of developing consensus definitions and research guidelines. The proposed Framework is based on an iterative process including 3 annual Workshops, focused workgroups, and input from numerous international investigators. It suggests the overarching term: resilience, and presents operational definitions for 3 concepts: cognitive reserve, brain maintenance, and brain reserve. Twelve pilot studies that integrate these definitions are presented. The use of a common vocabulary and operational definitions will facilitate even greater progress in understanding the factors that are associated with successful aging.

Original languageEnglish (US)
Pages (from-to)100-103
Number of pages4
JournalNeurobiology of Aging
StatePublished - Apr 2023


  • Brain maintenance
  • Brain reserve
  • Cognitive reserve
  • Resilience

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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