A DNA Polymerase α-Associated 56 kDa Protein Kinase

Vickie M. Peck; Eugene W. Gerner; Anne E. Cress

doi:10.1006/bbrc.1993.1051

A DNA Polymerase α-Associated 56 kDa Protein Kinase

Vickie M. Peck
, Eugene W. Gerner
, Anne E. Cress

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Initiation of chromosomal DNA replication must be carefully regulated during the cell cycle. We report that Drosophila embryo DNA polymerase α complex, isolated by immunological techniques, contains a protein kinase activity. The kinase will phosphorylate histone H1, but prefers peptides contained in the DNA polymerase α-kinase complex. Renaturation experiments determined that the kinase activity resides in a 56-kDa peptide.

Original language	English (US)
Pages (from-to)	325-331
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	190
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1993.1051
State	Published - 1993

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1006/bbrc.1993.1051

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title = "A DNA Polymerase α-Associated 56 kDa Protein Kinase",

abstract = "Initiation of chromosomal DNA replication must be carefully regulated during the cell cycle. We report that Drosophila embryo DNA polymerase α complex, isolated by immunological techniques, contains a protein kinase activity. The kinase will phosphorylate histone H1, but prefers peptides contained in the DNA polymerase α-kinase complex. Renaturation experiments determined that the kinase activity resides in a 56-kDa peptide.",

author = "Peck, \{Vickie M.\} and Gerner, \{Eugene W.\} and Cress, \{Anne E.\}",

year = "1993",

doi = "10.1006/bbrc.1993.1051",

language = "English (US)",

volume = "190",

pages = "325--331",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

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T1 - A DNA Polymerase α-Associated 56 kDa Protein Kinase

AU - Peck, Vickie M.

AU - Gerner, Eugene W.

AU - Cress, Anne E.

PY - 1993

Y1 - 1993

N2 - Initiation of chromosomal DNA replication must be carefully regulated during the cell cycle. We report that Drosophila embryo DNA polymerase α complex, isolated by immunological techniques, contains a protein kinase activity. The kinase will phosphorylate histone H1, but prefers peptides contained in the DNA polymerase α-kinase complex. Renaturation experiments determined that the kinase activity resides in a 56-kDa peptide.

AB - Initiation of chromosomal DNA replication must be carefully regulated during the cell cycle. We report that Drosophila embryo DNA polymerase α complex, isolated by immunological techniques, contains a protein kinase activity. The kinase will phosphorylate histone H1, but prefers peptides contained in the DNA polymerase α-kinase complex. Renaturation experiments determined that the kinase activity resides in a 56-kDa peptide.

UR - https://www.scopus.com/pages/publications/0027237349

UR - https://www.scopus.com/pages/publications/0027237349#tab=citedBy

U2 - 10.1006/bbrc.1993.1051

DO - 10.1006/bbrc.1993.1051

M3 - Article

C2 - 8427578

AN - SCOPUS:0027237349

SN - 0006-291X

VL - 190

SP - 325

EP - 331

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

A DNA Polymerase α-Associated 56 kDa Protein Kinase

Abstract

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