Abstract
Initiation of chromosomal DNA replication must be carefully regulated during the cell cycle. We report that Drosophila embryo DNA polymerase α complex, isolated by immunological techniques, contains a protein kinase activity. The kinase will phosphorylate histone H1, but prefers peptides contained in the DNA polymerase α-kinase complex. Renaturation experiments determined that the kinase activity resides in a 56-kDa peptide.
Original language | English (US) |
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Pages (from-to) | 325-331 |
Number of pages | 7 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 190 |
Issue number | 2 |
DOIs | |
State | Published - 1993 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology