A Distribution-Free Model for Longitudinal Metagenomic Count Data

Dan Luo, Wenwei Liu, Tian Chen, Lingling An

Research output: Contribution to journalArticlepeer-review


Longitudinal metagenomics has been widely studied in the recent decade to provide valuable insight for understanding microbial dynamics. The correlation within each subject can be observed across repeated measurements. However, previous methods that assume independent correlation may suffer from incorrect inferences. In addition, methods that do account for intra-sample correlation may not be applicable for count data. We proposed a distribution-free approach, namely CorrZIDF, which extends the current method to model correlated zero-inflated metagenomic count data, offering a powerful and accurate solution for detecting significance features. This method can handle different working correlation structures without specifying each margin distribution of the count data. Through simulation studies, we have shown the robustness of CorrZIDF when selecting a working correlation structure for repeated measures studies to enhance the efficiency of estimation. We also compared four methods using two real datasets, and the new proposed method identified more unique features that were reported previously on the relevant research.

Original languageEnglish (US)
Article number1183
Issue number7
StatePublished - Jul 2022


  • correlation structure
  • distribution-free
  • longitudinal
  • metagenomic
  • microbial
  • zero-inflated count model

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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