@article{3df70ef5abfd4f6b863715f63a8e777a,
title = "A Decarboxylative C(sp3)−N Bond Forming Reaction to Construct 4-Imidazolidinones via Post-Ugi Cascade Sequence in One Pot",
abstract = "A post-Ugi one-pot cascade was developed to access 4-imidazolidinones through an intramolecular decarboxylative C(sp3)−N bond forming reaction. The reaction has a broad tolerance for a variety of substituted aldehydes, anilines, isocyanides and glyoxylic acids. The cascade reaction scope was expanded to synthesize spiroimidazolidinone by the replacement of aldehyde with aliphatic ketone in the Ugi reaction. Subsequently, the methodology was applied to synthesize the core structures of pharmaceuticals GSK2137305 and SCH 900822 under the mild and facile conditions with one purification. This cascade reaction generates opportunities for the tailored synthesis of a range of biologically active 4-imidazolidinones through tuneable Ugi inputs. (Figure presented.).",
keywords = "4-Imidazolidinones, Decarboxylation, Multicomponent reactions (MCRs), One-pot, Spiroimidazolidinone",
author = "Song, {Gui Ting} and Qu, {Chuan Hua} and Jie Lei and Wei Yan and Tang, {Dian Yong} and Li, {Hong yu} and Chen, {Zhong Zhu} and Xu, {Zhi Gang}",
note = "Funding Information: The authors would like to thank the National Natural Science Foundation of China (No. 21901029), Chongqing Natural Science Foundation Postdoctoral Science Foundation Project (cstc2019jcyj-bshX0053), the Science and Technology Research Program of Chongqing Municipal Education Commission (KJQN201901345 and KJQN201901346) and the Scientific Research Foundation of the Chongqing University of Arts and Sciences (R2019FXY11). We would also like to thank Ms H.Z. Liu and J. Xu for obtaining the LC/MS, HRMS and NMR data. Funding Information: The authors would like to thank the National Natural Science Foundation of China (No. 21901029), Chongqing Natural Science Foundation Postdoctoral Science Foundation Project (cstc2019jcyj‐bshX0053), the Science and Technology Research Program of Chongqing Municipal Education Commission (KJQN201901345 and KJQN201901346) and the Scientific Research Foundation of the Chongqing University of Arts and Sciences (R2019FXY11). We would also like to thank Ms H.Z. Liu and J. Xu for obtaining the LC/MS, HRMS and NMR data. Publisher Copyright: {\textcopyright} 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2020",
month = oct,
day = "6",
doi = "10.1002/adsc.202000736",
language = "English (US)",
volume = "362",
pages = "4084--4091",
journal = "Advanced Synthesis and Catalysis",
issn = "1615-4150",
publisher = "Wiley-VCH Verlag",
number = "19",
}