A Critical Appraisal of Implantable Cardioverter-Defibrillator Therapy for the Prevention of Sudden Cardiac Death

Roderick Tung, Peter Zimetbaum, Mark E. Josephson

Research output: Contribution to journalReview articlepeer-review

280 Scopus citations

Abstract

The indications for implantable cardioverter-defibrillators (ICDs) for the prevention of sudden cardiac death have rapidly expanded over the past 10 years. Clinical trial data have quickly been implemented into guidelines without critical reassessment of the strengths and limitations of the evidence. ICD therapy has inherent risks including infection, unnecessary shocks, potential for proarrhythmia, device malfunction, highly publicized manufacturer advisories, and procedural complications, which can adversely affect morbidity and quality of life. A reappraisal of the benefits and potential hazards of ICD therapy will enable physicians to a have a more mutually informed and balanced dialogue with their patients.

Original languageEnglish (US)
Pages (from-to)1111-1121
Number of pages11
JournalJournal of the American College of Cardiology
Volume52
Issue number14
DOIs
StatePublished - Sep 30 2008
Externally publishedYes

Keywords

  • cost-effectiveness
  • defibrillator
  • proarrhythmia
  • sudden death
  • trials

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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