TY - JOUR
T1 - A convenient, room-temperature-organic base protocol for preparing chiral 3-(enoyl)-1,3-oxazolidin-2-ones
AU - Soloshonok, Vadim A.
AU - Ueki, Hisanori
AU - Jiang, Changchun
AU - Cai, Chaozhong
AU - Hruby, Victor J.
PY - 2002
Y1 - 2002
N2 - In this study, we developed a new protocol for the preparation of the chiral 3-[(E)-enoyl]-1,3-oxazolidin-2-ones under the ultimately simple reaction conditions starting with the corresponding enoyl chlorides and 1.3-oxazolidin-2-ones with Et3N/LiCl at room temperature. The method generally allows efficient preparation of various derivatives regardless of the steric and electronic nature of the substituents on both the enoyl or the oxazolidinone sites. Excellent yields, combined with the simplicity of the experimental procedures, render the present method immediately useful for preparing the target compounds.
AB - In this study, we developed a new protocol for the preparation of the chiral 3-[(E)-enoyl]-1,3-oxazolidin-2-ones under the ultimately simple reaction conditions starting with the corresponding enoyl chlorides and 1.3-oxazolidin-2-ones with Et3N/LiCl at room temperature. The method generally allows efficient preparation of various derivatives regardless of the steric and electronic nature of the substituents on both the enoyl or the oxazolidinone sites. Excellent yields, combined with the simplicity of the experimental procedures, render the present method immediately useful for preparing the target compounds.
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U2 - 10.1002/1522-2675(200211)85:11<3616::AID-HLCA3616>3.0.CO;2-O
DO - 10.1002/1522-2675(200211)85:11<3616::AID-HLCA3616>3.0.CO;2-O
M3 - Article
AN - SCOPUS:0036942301
SN - 0018-019X
VL - 85
SP - 3616
EP - 3623
JO - Helvetica Chimica Acta
JF - Helvetica Chimica Acta
IS - 11
ER -